After obtaining approval from institutional ethics committee, and written informed consent, the present study entitled "To Observe the Effect of Oral Gabapentin, Theophylline and Caffeine on SBP, DBP, MAP and HR" was conducted on 120 patients of ASA grade I &II scheduled for elective and emergency lower segment caesarean section under spinal anesthesia in the Department of Anesthesiology, J.A. Group of Hospitals & G.R. Medical College, Gwalior (M.P.) after getting written informed consent from the patients. No significant effects on haemodynamic parameters were observed with all the study drugs. Recurrence of PDPH was significantly high with caffeine treatment. No serious untoward effects or complications of study drugs were observed in the study. Keywords: Oral Gabapentin, Theophylline, Caffeine, SBP, DBP, MAP & HR.
Study was conducted on 60 patients of both sexes taken for various surgical procedures taking from 30 to 90 minutes at Gajra Raja Medical College, Gwalior. We found that none of the children in the 0.75 mg/kg dose group cried compared with 4 children (20%) in the c group and one child (5%) in the 0. 5 mg/kg dose group. The percentage of children who appeared uncomfortable (study recorded that they were crying or complaining) were the highest in the control dose group (45%). Only 25% of the children in the 0.5 mg/kg dose group and 10% of the children in the 0.75 mg/kg dose group appeared uncomfortable. Thus more children were comfortable (study recorded they were sleepy or quite but awake) in the 0.75 mg/kg dose group (90%) compared with the 0. 5 mg/kg dose group (75%) and the control group (55%). This difference was statistically significant between the control group and the group that received the 0.75mg/kg dose. The number of children who had desirable sedation was similar in the 0.75 mg/kg dose groups. Induction of general anaesthesia was poor for 25% the children in the group that received the 0.5 mg/kg dose. Keywords: Efficacy, Midazolam, Sedation & Anaesthesia.
Background: The purpose of the study is Isobaric 0.75% Ropivacaine 3.5ml (26.25mg) Intrathecally for Lower Limb Surgeries to Evaluate Perioperative Hemodynamic. Fifty patients admitted to our hospital undergoing lower extremity surgeries under spinal anesthesia. Subjects and Methods: Pre-anesthetic assessment was done prior to the day of surgery which included past history of chronic illness and medication, drug therapy (especially corticosteroids, anti hypertensive, anti coagulant, anti diabetic, anti convulsant medications), drug sensitivity and past anesthetic experience along with routine investigations including, haemoglobin, random blood sugar, serum urea, serum creatinine, and serum electrolytes, chest X-ray, ECG. Fifty patients admitted to our hospital undergoing lower extremity surgeries under spinal anesthesia included in the study. Results: Patients in the age group 18 – 60 years were selected including 45 males and 5 females. Thirty-Nine patients had an ASA grade I and 11 patients had an ASA grade II. The duration of surgeries ranged from 45 to 270 minutes & there were no significant changes in the pulse rate perioperatively. Conclusion: A study was conducted in 50 patients belonging to ASA grade I and II posted for lower limb surgeries. They received 3.5ml of 0.75% isobaric Ropivacaine in L2-3 interspace. All patients were preloaded with 1000 ml of ringer lactate. Following institution of subarachoid block sensory characteristics such as onset of sensory block, maximum level achieved, duration of sensory block and request for first dose of rescue analgesics were studied. We found the requirement for postoperative analgesics was 218.97 minutes. Hemodynamic parameters were stable in most of the patients. Postoperative side effects included shivering, nausea. Thus we conclude that isobaric 0.75% ropivacaine 26.25 mg, 3.5 ml when administered intrathecally in L2-3 interspace provides an adequate sensory block for lower limb surgeries, which makes it a good choice for lower limb surgeries with benefits of early ambulation.
The study was undertaken in the Department of Anaesthesiology, Gajra Raja Medical College, Gwalior. The study included 90 patients (age 20-35 years) undergoing elective caesarean section under spinal anaesthesia. Maximum hypotension was observed in control group. As compared to the control group, incidence of hypotension was significantly less in phenylephrine group as well as ephedrine group. Also comparing ephedrine and phenylephrine groups, although incidence of hypotension was low in phenylephrine group but it was not found to be significant. The incidence of hypotension was significantly low in phenylephrine group (p=0.000) and ephedrine group (p=0.005). But when phenylephrine and ephedrine groups were compared, although incidence of hypotension was low in phenylephrine group but it was not found to be significant (p=0.869). Keywords: Intravenous Vasopressor, Spinal Anaesthesia, Hypotension & Phenylephrine.
Background: The purpose of the investigation is to Compare Isobaric 0.5% Levobupivacaine With Isobaric 0.5% Ropivacaine In Brachial Plexus Block For Elective Upper Limb Surgery. Subjects and Methods: Intravenous access was obtained in the limb opposite to that undergoing surgery with an intravenous cannula-18G. Standard monitors, ECG, pulse oximeter, non invasive blood pressure, respiratory monitoring were connected and monitored continuously in all the patients and recorded at interval of 0, 5, 10, 15, 20, 30, 60 minutes in the first hour and every 30 minutes thereafter till the end of surgery. All emergency equipments including intubation aids and drugs such as midazolam, thiopentone or propofol and 20% of lipid emulsion were kept ready to deal with any adverse events during the course of procedure/ surgery. Sixty patients aged between 18yrs and 60yrs physical status ASA grade 1 and ASA grade 2 undergoing elective upper limb surgeries were included in the study. Results: Demographic details Age, sex and weight were comparable in both the groups (no significant statistical difference was observed). These eliminated possible bias in term of gender, age, and weight distribution which can alter the study drugs pharmacokinetics and dynamics. The average pulse rate, mean arterial pressure, oxygen saturation and respiratory rate readings at frequent intervals did not differ significantly between two intervention groups ( p> 0.05 for all) No clinically significant bradycardia or hypotension was noted. Conclusion: Levobupivacaine should be considered for peripheral nerve block when postoperative analgesia is a concern but not when an early return of motor function is desired in postoperative period for upper limb elective surgeries. Demographic details Age, sex and weight were comparable in both the groups (no significant statistical difference was observed). These eliminated possible bias in terms of gender, age, and weight distribution which can alter the study drug pharmacokinetics and dynamics. The average pulse rate, mean arterial pressure, oxygen saturation and respiratory rate readings at frequent intervals did not differ significantly between two intervention groups ( p> 0.05 for all) No clinically significant bradycardia or hypotension was noted.
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