This is the protocol for a review and there is no abstract. The objectives are as follows: 1. To review the effectiveness of supported employment compared to other approached to vocational rehabilitation and treatment as usual. 2. Secondary objectives are to establish how far: a. fidelity to the IPS model affects the effectiveness of supported employment, b. the effectiveness of supported employment can be augmented by the addition of other interventions.

This is the protocol for a review and there is no abstract. The objectives are as follows: To review the effectiveness of supported employment compared to other approached to vocational rehabilitation and treatment as usual.Secondary objectives are to establish how far: fidelity to the IPS model affects the effectiveness of supported employment,the effectiveness of supported employment can be augmented by the addition of other interventions.

d-Serine is abundant in the forebrain and physiologically important for modulating excitatory glutamatergic neurotransmission as a coagonist of synaptic N-methyl-d-aspartate (NMDA) receptor. NMDA signaling has been implicated in the control of food intake. However, the role of d-serine on appetite regulation is unknown. To clarify the effects of d-serine on appetite, we investigated the effect of oral d-serine ingestion on food intake in three different feeding paradigms (one-food access, two-food choice, and refeeding after 24-h fasting) using three different strains of male mice (C57Bl/6J, BKS, and ICR). The effect of d-serine was also tested in leptin signaling-deficient db/db mice and sensory-deafferented (capsaicin-treated) mice. The expression of orexigenic neuropeptides [neuropeptide Y (Npy) and agouti-related protein (Agrp)] in the hypothalamus was compared in fast/refed experiments. Conditioned taste aversion for high-fat diet (HFD) was tested in the d-serine-treated mice. Under the one-food-access paradigm, some of the d-serine-treated mice showed starvation, but not when fed normal chow. HFD feeding with d-serine ingestion did not cause aversion. Under the two-food-choice paradigm, d-serine suppressed the intake of high-preference food but not normal chow. d-Serine also effectively suppressed HFD intake but not normal chow in db/db mice and sensory-deafferented mice. In addition, d-serine suppressed normal chow intake after 24-h fasting despite higher orexigenic gene expression in the hypothalamus. d-Serine failed to suppress HFD intake in the presence of L-701,324, the selective and full antagonist at the glycine-binding site of the NMDA receptor. Therefore, d-serine suppresses the intake of high-preference food through coagonism toward NMDA receptors.

FNE was associated with delusional ideation both in non-clinical population and in patients with schizophrenia. FNE might be a potential target for both pharmacological and psychological interventions for patients with delusions.

was modified according to the reviewer's comment. *Response to ReviewersAbstract Purpose: Whether a low body mass index (BMI) is directly associated with high risk of suicidal ideation or self-harming behavior in adolescents is still inconclusive. This study has, therefore, evaluated the relevance of BMI to suicidal ideation and self-harming behavior after controlling for body weight perception (BWP) and other potential confounding factors.Methods: BMI, BWP, suicidal ideation and self-harming behavior were all assessed using a self-report questionnaire administered to 18,104 Japanese adolescents. Potential confounding factors were also evaluated. The data were then analyzed using bivariate and multivariate logistic regression.Results: Low BMI was associated with suicidal ideation and deliberate self-harm when controlling for sex, age, drug use, emotional distress and BWP.Conclusions: Low BMI may be an independent risk factor for suicidal ideation and deliberate self-harming behavior in Japanese adolescents.

The SCIPS is a promising tool with which to sub-group patients with schizophrenia according to this recently developed classification scheme. The semi-structured interview achieves acceptable inter-rater and test-retest reliability and concurrent validity.

We should no longer make light of public speaking fears among adolescents as transient, common-sense phenomena.

No abstract