Purpose Although breast density is considered a strong risk factor of breast cancer, its quantitative assessment is difficult. To investigate a quantitative method of measuring breast density using dual‐energy mammographic imaging with central digital breast tomosynthesis in physically uniform and nonuniform phantoms. Material and methods The dual‐energy imaging unit used a tungsten anode and silver filter with 30 kVp for high‐energy images and 20 kVp for low‐energy images. Uniform glandular‐equivalent phantoms were used to calibrate a dual‐energy based decomposition algorithm. The first study used uniform breast phantoms which ranged in thicknesses from 20 to 70 mm, in 10‐mm increments, and which provided 30%, 50%, and 70% of breast density. The second study used uniform phantoms ranging from 10% to 90% of breast density. The third study used non‐uniform phantoms (at an average density of 50%) with a thickness which ranged from 20 to 90 mm, in 10‐mm increments. Results The root mean square error of breast density measurements was 2.64–3.34% for the uniform, variable thickness phantoms, 4.17% for the uniform, variable density phantoms, and 4.49% for the nonuniform, variable thickness phantoms. Conclusion The dual‐energy technique could be used to measure breast density with a margin of error of < 10% using digital breast tomosynthesis.

The RIs of Taiwanese for A-IPF and IPF% were established. Furthermore, the analyzer detection method and the reference individuals contribute to the discrepancy of the RI for IPF% and should be considered cautiously when the value of IPF is interpreted.

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