Big-bubble DALK is effective in patients with keratoconus with stromal scars. Scar depth/MCT ratio seems to predict the DM perforation.

Purpose To evaluate the effects of air bubbles on clear corneal incision (CCI) in patients who had phacoemulsification surgery, and to compare this type of CCI architecture with patients who had no air bubbles after phacoemulsification surgery, using anterior segment optical coherence tomography (AS-OCT). Methods Eyes which had undergone uneventful phacoemulsification cataract surgery with implantation of a posterior chamber intraocular lens (IOL) were equally randomized into two groups. Group 1 comprised patients with anterior chamber air bubble injection after phacoemulsification, and Group 2 comprised patients who had undergone phacoemulsification surgery without anterior chamber air bubble. Postoperative evaluation included AS-OCT (Heidelberg Engineering, Germany) and pneumatic tonometry (Nidek NT-1000 Pneumatic Tonometer, Japan) in the 2nd hour, then at 1 week, and 1 month. Astigmatic changes assessed with corneal topography after phacoemulsification cataract surgeries were noted. Results Evaluation was made of 40 eyes of 28 patients (10 female, 18 male) as 20 eyes in Group 1 and 20 eyes in Group 2. On the first postoperative day, the endothelial gap rate was 13.3% in Group 1 and 57.1% in Group 2 ( P = 0.02), and this continued until the 1-month follow-up examination. The Descemet's membrane detachment (DMD) rate was 0% in Group 1 and 42.8% in Group 2 on postoperative day 1 ( P = 0.006), and this continued at the 1-month follow-up examination. At 1 month postoperatively, the rates of optical coherence tomography (OCT) parameters were similar. There were no significant differences between preoperative astigmatism and postoperative astigmatism in the group analyses. Conclusion In this study, air bubbles decreased the rate of DMD and of endothelial and epithelial gap during the early postoperative period.

Repeated doses of systemic bevacizumab did not cause a deleterious effect on healthy eyes of cancer patients clinically, but further studies including histologic and biochemical analysis need to be conducted to reveal possible adverse effects.

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The aim of this study was to evaluate the smoking effect on peripapillary and macular microvascular structure in patients with inactive Graves' ophthalmopathy (GO) and to compare these structures with those of healthy control subjects. MethodsA total of 34 healty participants (control group), 22 inactive GO patients with smoking (smoker group) and 19 inactive GO patients with nonsmoking (non-smoker group) were recruited in this prospective study. After detailed ophthalmological examination, vessel densities (VD) of the super cial capillary plexus (SCP), deep capillary plexus (DCP), retinal peripapillary capillary (RPC) and foveal avascular zone (FAZ) area, acircularity index (AI) of the FAZ were analyzed with optical coherence tomography angiography (OCTA) for each eye. ResultsVessel density in the total peripapillary; superior and inferior sectors of RPC were signi cantly lower in inactive GO patients with smoking (p<0.05 for all sectors) compared to control group. Besides, the FAZ AI was signi cantly higher in smoker and non-smoker inactive GO groups compared to healthy subjects (p=0.0001, p=0.0001, respectively). No signi cant difference was found in the FAZ area, and all SCP, DCP macular measurements between groups (p>0.05 for all). ConclusionOCTA ndings of lower peripapillary VD in the smoker group show smoking effect on the optic disc head microvasculature in inactive GO patients. These results could re ect early subclinical optic disc vasculature damage in smoker inactive GO subjects.