IntroductionActinomycetes are bona fide producers of new antibiotic agents 1 . Most of the commercialised antibiotics have been discovered from Actinomycetes by screening natural soil and water habitats 2 5 . A wide taxonomic range of Actinomycetes also has the ability to produce many other secondary metabolites with biological activities including anticancer, antiviral, and immunosuppressant 6 10 . Despite the increase in resistance to commonly used antibiotics, new antimicrobial agents are being constantly searched from novel Actinomycetes isolates 11,12 .Many new types of Actinomycetes have been characterised and named, and their secondary metabolites have been extracted using various techniques 4,13 .Most Actinomycetes are free-living organisms that are widely distributed in nature. They are found in both aquatic and terrestrial habitats. The survival rate of these bacteria in unsuitable environmental conditions is high 14 .Actinomycetes are grouped phylogenetically as Grampositive bacteria with high guanine and cytosine content in their genome. They provide approximately 75 of the current bioactive compounds. Species of Streptomyces alone produce two-thirds of naturally occurring antibiotics worldwide 15 .
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