The aim of the study was to study the dynamics of myocardial function indicators in overweight patients at different stages of rehabilitation after coronary revascularization.Material and methods. This article presents the interim results of prospective study which was conducted at the Tulpar cardiorehabilitation center (Karaganda, Kazakhstan). The study included 135 patients after restoration of blood flow in the coronary arteries (coronary artery bypass grafting, stenting). The average age was 58 ± 6 years. Exclusion criteria: acute myocardial infarction; chronic heart failure, functional class III–IV; acute disorders of cerebral circulation; diabetes mellitus in a state of decompensation; obesity I–III degree. We observed patients in dynamics at three stages of rehabilitation. 41 patients were included in the study at the first stage, 43 – at the second stage and 51 – at the third stage. Patients were included from different stages of rehabilitation. The groups were comparable in terms of the parameters of the structural and functional state of the myocardium, the same age range.Results. Considering the size of the interventricular septum, the posterior wall of the left ventricle, the relative thickness of the myocardium and the myocardial mass index, it can be noted that statistically significant hypertrophy of the left ventricle was observed in all observation periods (p < 0.05).Conclusions. In overweight patients who underwent myocardial revascularization surgery, persistent changes in the myocardium remain at the 3rd stage of rehabilitation
Background: Measles is a significant public health problem in India and many other developing countries. A single dose of measles vaccine is administered at 9 months of age, assuming that infants are protected by transplacental antibodies till this age.Objective: In infants born to unimmunized mothers, to (i)serially measure the level of anti-measles antibodies from birth to 9 months, (ii)study the pattern of decline, and (iii)identify possible factors that could predict lack of protection.Methods & Materials: Institutional ethical clearance was obtained. Written informed consent was taken from women preparing to deliver babies in the hospital. Serum anti-measles IgG was measured by quantitative ELISA in 61 consecutively born infants at birth (cord blood from infant side), 14 weeks (coinciding with visit for EPI vaccination), 24 weeks (coinciding with visit for third dose Hepatitis B vaccine) and 36weeks (just before measles vaccination). Proportion of unprotected infants (antibody titre <200 mIU/ml) was calculated at each time-point. Gestational age (preterm vs term), gestational weight (small-for-age vs appropriate-for-age), initial antibody level at birth, were evaluated as possible predictors.Results: Anti-measles IgG antibody levels (±standard deviation) were 3235±169 IU/ml at birth, 994±127 IU/ml at 14weeks, 208±34 IU/ml at 24 weeks, and 85±8 IU/ml at 36weeks (Figure 1A and 1B). The proportion of unprotected infants was 0%, 11.5%, 72%, and 94% respectively. Lack of protection did not correlate with premature birth (odds ratio; 95% CI for preterm vs term was 0.90; 95%CI 0.26, 3.10 at 14weeks, and 0.40; 95%CI 0.04, 3.56 at 24 weeks). There was also no relationship to birth weight (odds ratio; 95% CI for SGA vs AGA was 1.63; 0.33, 8.11 at 14 weeks and 0.86, 95%CI 0.26,2.78 at 24 weeks).Conclusion: Majority of infants lose transplacental anti-measles antibodies between 14 and 24 weeks of age, and are susceptible to measles. The lack of protection cannot be predicted by gestational age or birth weight.
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