Urticarial vasculitis is a skin disease characterized by recurrent urticarial lesions and histological features of leukocytoclastic vasculitis. Urticarial vasculitis is known to occur in the association with various infectious diseases, including chronic hepatitis C virus. However, the clinical features of urticarial vasculitis associated with hepatitis C virus have not been systematically characterized, which complicates the management of these patients. This review presents an analysis of published clinical, histological and laboratory findings in patients with urticarial vasculitis in the association with chronic hepatitis C virus, which can be helpful for early diagnosis and optimization of the patient management. We performed a Pubmed search to identify clinical cases from 1971 to 2022 using the keywords "urticarial vasculitis", "hepatitis C virus infection". According to the inclusion/exclusion criteria, 13 clinical cases of urticarial vasculitis associated with hepatitis C virus were included in the analysis. Clinical manifestations were urticarial rashes (n=13), associated with residual hyperpigmentation in 8 patients, tenderness/burning ― in 7 patients, and a lesion duration (24 hours) ― in five patients. Arthralgias were described in 3 patients. On histological examination, there were fibrinoid necrosis (n=2); leukocytoclasia (n=4); erythrocyte extravasation (n=1); dermis edema (n=2); perivascular infiltrate consisting of neutrophils (n=5), eosinophils (n=4), lymphocytes (n=3), and histiocytes (n=2). Hypocomplementemia was reported in eight patients. The laboratory work revealed cryoglobulinemia (n=9) and positive rheumatoid factor (n=6), which were the characteristic findings in the association of these diseases. The association of urticarial vasculitis and chronic hepatitis C virus is an important interdisciplinary problem that requires an interaction of dermatologists, allergists, hepatologists, rheumatologists and infectious disease doctors. Histological examination is indicated to differentiate between urticaria and urticarial vasculitis in patients with atypical urticarial lesions. Early detection of chronic hepatitis C virus is necessary for the timely administration of antiviral therapy. The urticarial vasculitis treatment should be selected taking into account their efficacy and the risk of hepatotoxicity.
Cylindroma is a rare benign tumor derived from the skin appendages, its typical localization is head and neck. The histogenesis of the disease is unknown, cylindromas are thought to develop from the epithelial ducts of the eccrine or apocrine glands, or represent a neoplastic proliferation of epithelial stem cells. The clinical presentation of the disease includes single or multiple smooth nodules and nodes of a pale pink color. Branching vessels are often visualized on their surface. There are two types of this tumor: sporadic genetically not determined сylindroma and inherited in an autosomal dominant manner multiple сylindroma. Multiple cylindroma may cause a lesion on the scalp that looks like a turban, due to the fusion and an increasing size of the nodules. Therefore, cylindroma are sometimes called a turban tumor. The treatment of multiple cylindroma is a serious interdisciplinary problem due to the large area of the lesion, abundant blood supply to the scalp and the tendency of the disease to recur. The treatment methods described in the literature include traditional surgical excision, electrocoagulation, laser, Mohs micrographic surgery. In this article we present a rare clinical case of a young male diagnosed with multiple cylindroma.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.