The price that many young men pay for the curative treatment of malignant disease is infertility. It has been appreciated for many years that anti-cancer treatment may result in azoospermia (Sutcliffe, 1987), which is frequently permanent (Da Cunha et al., 1984). The damage to the testes depends partly on the choice of drug -alkylating agents do the most harm (Roeser et al., 1978;Miller, 1971) -and partly on the duration of exposure (Waxman, 1985
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