Introduction: To assess the level of anxiety and knowledge regarding COVID-19 amongst antenatal women. Materials and Methods: This cross-sectional survey was conducted in the antenatal clinics of KK Women’s and Children’s Hospital, Singapore, from 31 March to 25 April 2020 to assess pregnant women’s knowledge of COVID-19, their perceptions of its impact upon pregnancy and psychological impact using the validated Depression, Anxiety, and Stress Scales (DASS-21). Results: Of the 324 women who participated in the study, the mean age was 31.8 years (range, 20–45). The majority (53.7%) were multiparous with mean gestational age of 23.4 weeks (SD 10). The commonest sources of information were Internet-based social media platforms. A significant proportion were unaware, or associated COVID-19 infection during pregnancy with fetal distress (82.1%), intrauterine death (71.3%), fetal anomalies (69.8%), miscarriages (64.8%), preterm labour (67.9%) and rupture of membranes (61.4%). A total of 116 (35.8%) women screened positive for anxiety, 59 (18.2%) for depression, and 36 (11.1%) for stress. There was a significant association between household size and stress scores [B = 0.0454 (95% CI, 0.0035–0.0873)]. Women who associated COVID-19 infection with fetal anomalies and intrauterine fetal death had significantly higher anxiety scores [B = −0.395 (95% CI, −0.660 to −0.130) and B = −0.291 (95% CI, −0.562 to −0.021) respectively]. Conclusion: Our study highlights that a lack of timely and reliable information on the impact of COVID-19 on pregnancy and its outcomes results in increased levels of depression, anxiety and stress. The healthcare provider must address these issues urgently by providing evidence-based information using Internet-based resources and psychological support. Key words: Depression, Anxiety, Stress, Pregnancy, Knowledge
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