Levonadifloxacin (intravenous) and its oral prodrug alalevonadifloxacin are broad-spectrum antibacterial agents developed for the treatment of difficult-to-treat infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus, atypical bacteria, anaerobic bacteria, and biodefence pathogens as well as Gram-negative bacteria. Levonadifloxacin has a well-defined mechanism of action involving a strong affinity for DNA gyrase as well as topoisomerase IV. Alalevonadifloxacin with widely differing solubility and oral bioavailability has pharmacokinetic profile identical to levonadifloxacin. Unlike existing MRSA drugs such as vancomycin and linezolid, which cause unfavorable side effects like nephrotoxicity, bone-marrow toxicity, and muscle toxicity, levonadifloxacin/alalevonadifloxacin has demonstrated superior safety and tolerability features with no serious adverse events. Levonadifloxacin/alalevonadifloxacin could be a useful weapon in the battle against infections caused by resistant microorganisms and could be a preferred antibiotic of choice for empirical therapy in the future.
We present a rare case with simultaneous COVID-19 pneumonia and acute complicated type B aortic dissection (ACTBAD). With strained health services a major procedure endovascular aortic repair (EVAR) was performed. Despite successful EVAR, patient had sudden unexplained cardiac arrest. The risk of post procedural mortality is high among COVID-19 infected patients.
One of the major causes of reversible left ventricular (LV) systolic dysfunction is takotsubo cardiomyopathy. It is characterized by angina, dyspnea, electrocardiogram changes (ST segment elevation and T wave changes on chest leads of electrocardiogram), echocardiographic changes (LV dysfunction with predominant apical involvement), elevation of troponin and brain natriuretic peptide, usually mimicking acute coronary syndrome. Coronary angiogram in such cases is either normal or shows only insignificant coronary disease. Although LV apical involvement is the commonest manifestation, about one-fifth of cases of takotsubo cardiomyopathy have normal apical contractility but severe systolic dysfunction of the basal segments of the left ventricle. We report a case of reverse takotsubo cardiomyopathy developed in a relatively young patient following hip surgery and how three-dimensional and strain echocardiography clearly demonstrated the abnormality and aided the recovery of the patient.
Giant right ventricular thrombus is a rare characteristic of pulmonary thrombosis-embolism that is typically associated with chronic obstructive pulmonary disease (COPD) exacerbation. We found such a giant right ventricular thrombus in a patient who was a heavy smoker who had extreme type of COPD with cor pulmonale. He also had hypotension, hypoxia, low tolerance for exercise, congestive heart failure, and poor quality of life, which are the prognostic qualities in the patient's clinical scenario we mentioned.
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