World is facing agrarian as well as nutritional challenges. Agricultural lands with irrigation facilities have been exploited to maximum, and hence we need to focus on dry lands to further increase grain production. Owing to low fertility, utilization of dry lands to produce sufficient quality grains is a big challenge. Millets as climate change compliant crops score highly over other grains like wheat and rice in terms of marginal growing conditions and high nutritional value. These nutri-cereals abode vitamins, minerals, essential fatty acids, phyto-chemicals and antioxidants that can help to eradicate the plethora of nutritional deficiency diseases. Millets cultivation can keep dry lands productive and ensure future food and nutritional security.
Acute renal failure (ARF) occurs in wide range of conditions, making the evaluation of its prognosis a difficult task. Data regarding prognostic factors in ARF in a general population in developing countries are scarce. The objective of the study was to describe predictors of mortality in ARF that are relevant in the developing world. This prospective study was carried out over a one-year period; all hospitalized adults with ARF were included in the study. Predictors of mortality studied included causes of ARF, pre-existing diseases, and severity as well as complications of ARF. Of 33,301 patients admitted during the study period, 294 (0.88%) were either admitted with or developed ARF after hospitalization. Mean age was 43.9 ± 16.9 (18-86 yrs). Sepsis was the most common cause (63.26%). Pre-existing diseases like cardiovascular disease (CVSD), respiratory system disease (RSD), central nervous system disease (CNSD), hypertension, diabetet mellitus (DM), and malignancy were significantly higher in elderly as compared to younger patients. On univariate analysis sepsis, hypoperfusion as a cause of ARF and hospital-acquired ARF were associated with higher mortality. Pre-existing diseases viz. RSD, CVSD, CNSD, and DM had higher mortality. Among the severity and complications of ARF, oliguria, bleeding and infection during the course of ARF and critical illness were predictors of poor outcome. Age >60 yrs was associated with significantly higher mortality. However, on multivariate analysis, only critical illness (odds ratio 37.3), age > 60 years (odds ratio of 5.6), and sepsis as cause of ARF (odds ratio of 2.6) were found to be independent predictors of mortality.
In India, there are marked variations in resources for cervical cancer screening. For the first time, resourcestratified screening guidelines have been developed that will be suitable for low middle-income countries with similar diversities. The current article describes the process and outcomes of these resource stratified guidelines for screening and treatment of preinvasive lesions of cervix. Evidence from literature was collated and various guidelines were reviewed by an expert panel. Based on the level of evidence, guidelines were developed for screening by human papillomavirus (HPV) testing, cytology and visual inspection after application of acetic acid (VIA), and management of screen positive lesions in different resource settings. Expert opinion was used for certain country-specific situations. The healthcare system was stratified into two resource settingsgood or limited. The mode of screening and treatment for each was described. HPV testing is the preferred method for cervical cancer screening. VIA by trained providers is especially suitable for low resource settings until an affordable HPV test becomes available. Healthcare providers can choose the most appropriate screening and treatment modality. A single visit approach is encouraged and treatment may be offered based on colposcopy diagnosis ('see and treat') or even on the basis of HPV test or VIA results ('screen and treat'), if compliance cannot be ensured. The Federation of Obsterician and Gynaecologists of India Good Clinical Practice Recommendations (FOGSI) GCPR are appropriately designed for countries with varied resource situations to ensure an acceptable cervical cancer prevention strategy.The three main modalities of screening in use are HPV testing, cytology and visual inspection with 202
Colocasia esculenta leaves possess vital nutritive and nonnutritive components in significant amounts, but are underutilized, and lesser explored. The chemical composition varies significantly depending upon climatic conditions and other agronomical factors of the location of cultivation and variety. Micronutrients, viz. iron (3.4–11.7 mg 100 g–1), copper (0.29–0.8 mg 100 g–1), magnesium (170–752 mg 100 g–1), potassium (0.4–2.4 g 100 g–1), and zinc (0.6–4.2 mg 100 g–1) are present in high amounts. The ratio of sodium to potassium (1:40) in the leaves add specifically to the antihypertensive properties. Preclinical and clinical studies provide evidence of its antidiabetic, antihemorrhagic, neuropharmacological properties, and as a remedy for stomach and liver ailments. Assessment of phytochemical compounds like chlorogenic acid, anthraquinones, cinnamic acid derivatives, and other phenolics validates these biological properties. The major limiting factor of this plant is oxalate that can be suppressed through food processing strategies. Colocasia leaves are promising green leafy vegetables with nutritional and clinical potential. Practical applications Colocasia leaves have demonstrated the ability of antidiabetic, antihypertensive, immunoprotective, neuroprotective, and anticarcinogenic activities. The detailed assessment of phytochemical compounds present in various extracts of the leaves shows the presence of active chemical compounds like anthraquinones, apigenin, catechins, cinnamic acid derivatives, vitexin, and isovitexin which are possibly responsible for the exhibited biological properties. Colocasia leaves are rich sources of micronutrients; however, the presence of oxalates can prohibit proper utilization of these nutrients. Various food processing strategies like soaking, cooking, and so on can significantly reduce the antinutritional content and make these nutrients available for utilization. Documentation of traditional uses and food products from Colocasia leaves show that these leaves have immense potential in the functional food product as well as drug development.
The present study was conducted to develop finger millet and oats based functional beverage. The nutricereals were ground into coarse flour and blended in various proportions (90:10–50:50) to prepare the drink. The functional drink, optimized using response surface methodology, was prepared using malt‐drink (diluted formulation of finger millet: oat in the ratio 60:40) and double toned milk (40:60–60:40). The final optimized product was found to be rich in dietary fibers (1.23%) viz. β‐glucan (101.33 mg/100 mL), and the antioxidants like total polyphenols (52.33 mg/100 mL). The drink was low in fat (1.26%), cholesterol (3.10 mg/100 mL), and lactose (1.75%). Sensory acceptability of the selected beverage (7.21) was at par with the sweetened cattle milk (7.52) on a 9‐point hedonic scale. The overall cost of ready to serve drink was INR 10 (serving size 200 mL), ensuring the economic feasibility of the drink.Practical applicationsFinger millet is a rich source of calcium, iron and zinc; and oats are rich in beta‐glucan. Incorporation of finger millet and oats improve the overall functional properties of milk. The complementation of the finger millet with oats can further enhance the physical as well as the functional properties of the milk. The dietary fiber content of the nutricereal based beverage was also increased, which makes it a potential prebiotic. The drink also provides an improved way for the introduction of millets in futuristic food products.
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