Transcranial direct current stimulation (tDCS) is increasingly used as a form of noninvasive brain stimulation to treat psychiatric disorders; however, its mechanism of action remains unclear. Prolonged visual stimulation (PVS) can enhance evoked EEG potentials (visually evoked potentials, VEPs) and has been proposed as a tool to examine long-term potentiation (LTP) in humans. The objective of the current study was to induce and analyze VEP plasticity and examine whether tDCS could either modulate or mimic plasticity changes induced by PVS. Thirty-eight healthy participants received tDCS, PVS, either treatment combined or neither treatment, with stimulation sessions being separated by one week. One session consisted of a baseline VEP measurement, one stimulation block, and six test VEP measurements. For PVS, a checkerboard reversal pattern was presented, and for tDCS, a constant current of 1 mA was applied via each bioccipital anodal target electrode for 10 min (Fig. S1). Both stimulation types decreased amplitudes of C1 compared to no stimulation (F = 10.1; p = 0.002) and led to a significantly smaller increase (PVS) or even decrease (tDCS) in N1 compared to no stimulation (F = 4.7; p = 0.034). While all stimulation types increased P1 amplitudes, the linear mixed effects model did not detect a significant difference between active stimulation and no stimulation. Combined stimulation induced sustained plastic modulation of C1 and N1 but with a smaller effect size than what would be expected for an additive effect. The results demonstrate that tDCS can directly induce LTP-like plasticity in the human cortex and suggest a mechanism of action of tDCS relying on the restoration of dysregulated synaptic plasticity in psychiatric disorders such as depression and schizophrenia.

The information available through our senses is noisy, incomplete, and to varying degrees ambiguous. The perceptual system must create stable and reliable percepts out of this restricted information. It solves this perceptual inference problem by integrating memories of previous percepts and making predictions about the perceptual future. Using ambiguous figures and a new experimental approach, we studied whether generating predictions based on regularities in the past affects processing of the present and how this is done. Event-related potentials (ERPs) were measured to investigate whether a highly regular temporal context of either ambiguous or unambiguous stimulus variants differently affects processing of a current stimulus and/or task execution. Further, we tested whether symbolic announcements about the immediate perceptual future can replace the past experience of regularities as a source for making predictions. Both ERP and reaction time varied as a function of stimulus ambiguity in the temporal context of a present stimulus. No such effects were found with symbolic announcements. Our results indicate that predictions about the future automatically alter processing of the present, even if the predictions are irrelevant for the present percept and task. However, direct experiences of past regularities are necessary for predicting the future whereas symbolic information about the future is not sufficient.

Current theories about visual perception assume that our perceptual system weights the a priori incomplete, noisy and ambiguous sensory information with previous, memorized perceptual experiences in order to construct stable and reliable percepts. These theories are supported by numerous experimental findings. Theories about precognition have an opposite point of view. They assume that information from the future can have influence on perception, thoughts, and behavior. Several experimental studies provide evidence for precognition effects, other studies found no such effects. One problem may be that the vast majority of precognition paradigms did not systematically control for potential effects from the perceptual history. In the present study, we presented ambiguous Necker cube stimuli and disambiguated cube variants and systematically tested in two separate experiments whether perception of a currently observed ambiguous Necker cube stimulus can be influenced by a disambiguated cube variant, presented in the immediate perceptual past (perceptual history effects) and/or in the immediate perceptual future (precognition effects). We found perceptual history effects, which partly depended on the length of the perceptual history trace but were independent of the perceptual future. Results from some individual participants suggest on the first glance a precognition pattern, but results from our second experiment make a perceptual history explanation more probable. On the group level, no precognition effects were statistically indicated. The perceptual history effects found in the present study are in confirmation with related studies from the literature. The precognition analysis revealed some interesting individual patterns, which however did not allow for general conclusions. Overall, the present study demonstrates that any future experiment about sensory or extrasensory perception urgently needs to control for potential perceptual history effects and that temporal aspects of stimulus presentation are of high relevance.

Weber's law is a fundamental psychophysical principle. It states that the just noticeable difference (JND) between stimuli increases with stimulus magnitude; consequently, larger stimuli should be estimated with larger variability. However, visually guided grasping seems to violate this expectation: When repeatedly grasping large objects, the variability is similar to that when grasping small objects. Based on this result, it was often concluded that grasping violated Weber's law. This astonishing finding generated a flurry of research, with contradictory results and potentially far-reaching implications for theorizing about the functional architecture of the brain. We show that previous studies ignored nonlinearities in the scaling of the grasping response. These nonlinearities result from, for example, the finger span being limited such that the opening of the fingers reaches a ceiling for large objects. We describe how to mathematically take these nonlinearities into account and apply this approach to our own data, as well as to the data of three influential studies on this topic. In all four datasets, we found that—when appropriately estimated—JNDs increase with object size, as expected by Weber's law. We conclude that grasping obeys Weber's law, as do essentially all sensory dimensions.

No abstract