Reactions of [Pt 2 (l-S) 2 (PPh 3 ) 4 ] with Ph 3 PbCl, Ph 2 PbI 2 , Ph 2 PbBr 2 and Me 3 PbOAc result in the formation of bright yellow to orange solutions containing the cations [Pt 2 (l-S) 2 (PPh 3 ) 4 PbR 3 ] + (R 3 = Ph 3 , Ph 2 I, Ph 2 Br, Me 3 ) isolated as PF 6 À or BPh 4 À salts. In the case of the Me 3 Pb and Et 3 Pb systems, a prolonged reaction time results in formation of the alkylated species [Pt 2 (l-S)(l-SR)(PPh 3 ) 4 ] + (R = Me, Et). X-ray structure determinations on [Pt 2 (l-S) 2 (PPh 3 ) 4 PbMe 3 ]PF 6 and [Pt 2 (l-S) 2 (PPh 3 ) 4 PbPh 2 I]PF 6 have been carried out, revealing different coordination modes. In the Me 3 Pb complex, the (four-coordinate) lead atom binds to a single sulfur atom, while in the Ph 2 PbI adduct coordination of both sulfurs results in a five-coordinate lead centre. These differences are related to the electron density on the lead centre, and indicate that the interaction of the heterometal centre with the {Pt 2 S 2 } metalloligand core can be tuned by variation of the heteroatom substituents. The species [Pt 2 (l-S) 2 (PPh 3 ) 4 PbR 3 ] + display differing fragmentation pathways in their ESI mass spectra, following initial loss of PPh 3 in all cases; for R = Ph, loss of PbPh 2 occurs, yielding [Pt 2 (l-S) 2 (PPh 3 ) 3 Ph] + , while for R = Me, reductive elimination of ethane gives [Pt 2 (l-S) 2 (PPh 3 ) 3 PbMe] + , which is followed by loss of CH 4 .
Chorea is a disorder characterized by irregular, involuntary, hyperkinetic movements and has various causes. One unusual cause is hyperglycemia. This case involves a 76-year-old diabetic Caucasian female who developed gait disturbances, hemichorea of the face and limbs, and slurred speech over two to three weeks. She was found to have glucose level of 690 mg/dL with HbA1c of 14.7%. Head CT demonstrated hyperdensity in the left basal ganglia and mild involvement of right basal ganglia. Treatment with insulin alleviated her symptoms. The exact pathophysiology is unknown; however, many theories exist.
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