We show that the centrosome- and microtubule-regulating protein γ-tubulin interacts with E2 promoter binding factors (E2Fs) to modulate E2F transcriptional activity and thereby control cell cycle progression. γ-Tubulin contains a C-terminal signal that results in its translocation to the nucleus during late G1 to early S phase. γ-Tubulin mutants showed that the C terminus interacts with the transcription factor E2F1 and that the E2F1–γ-tubulin complex is formed during the G1/S transition, when E2F1 is transcriptionally active. Furthermore, E2F transcriptional activity is altered by reduced expression of γ-tubulin or by complex formation between γ-tubulin and E2F1, E2F2, or E2F3, but not E2F6. In addition, the γ-tubulin C terminus encodes a DNA-binding domain that interacts with E2F-regulated promoters, resulting in γ-tubulin-mediated transient activation of E2Fs. Thus, we report a novel mechanism regulating the activity of E2Fs, which can help explain how these proteins affect cell cycle progression in mammalian cells.—Höög, G., Zarrizi, R., von Stedingk, K., Jonsson, K., Alvarado-Kristensson, M. Nuclear localization of γ-tubulin affects E2F transcriptional activity and S-phase progression.

This article asks what key concerns emerge from the way responsibility is framed in United Nations summit documents on the Sustainable Development Goals (SDGs) adopted in 2015. Our conceptual framework serves to make the study of SDG responsibility more systematic by distinguishing three main senses of responsibility: cause, obligation, and accountability. The framework structures our analysis of two SDG summit documents, Transforming Our World: The 2030 Agenda for Sustainable Development and the Addis Ababa Action Agenda. The article shows, first, that the causal sense of responsibility is hidden between the lines in paragraphs on poverty, debt and environmental issues. As a consequence, root causes of problems might not be appropriately addressed. Second, SDG summit documents deal predominantly with responsibility in the sense of obligation. We raise concerns with repeated consideration for national circumstances and with vague obligations for non-governmental actors. Third, with regard to accountability, we stress that quantitative indicators have unintended steering effects both before and beyond the review phase. The focus on indicators risks shadowing broader obligations, such as international human rights. In all its three senses, responsibility in key SDG documents remains statecentric with great room for state sovereignty, self-regulation and respect for national circumstances. Our framework is useful also in showing that the three senses of responsibility build on each other and that engagement with responsibility provides fruitful ground for further research.

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With the adoption of the Sustainable Development Goals (SDGs), debates on governance through goal-setting and performance review have gained momentum. In this article, we explore how the politics of performance review played out in public sustainable development reporting at the global-national nexus. By examining the case of Swedish reporting to the United Nations High Level Political Forum in 2017, we find policy translation, accountability preparation and identity formation to be key functions of SDG reporting. We draw attention to the performative and political features of these functions in the sustainable development realm. With a fast approaching deadline, policy translation of global indicators to the national context glossed over politically contentious issues. Reporting served to enable peer review among governments rather than hierarchical accountability of domestic politics. Moreover, the identity formation function of SDG reporting was strong on the international stage while domestically it was challenged by broader political struggles. In conclusion, our study bears witness of the formative power of public reporting for SDG governance. We call for comparative research to allow for further theory-building on the politics of public reporting on sustainable development.