Purpose: Staphylococcus aureus (SA) endophthalmitis is generally a postsurgical infection with an undefined source of entry. Hospital-acquired (HA) SA infections are associated with multi-antibiotic resistance and absence of the Panton-Valentine Leukocidin (PVL) toxin. Community-acquired (CA) SA infections are not associated with multi-antibiotic resistance and possess the PVL toxin. We hypothesize that CA infection is more common than HA for SA endophthalmitis. Methods: Twenty de-identified SA isolates, collected from the vitreous and/or aqueous of clinical endophthalmitis, were tested for the presence of PVL toxin and antibiotic susceptibility. PVL testing was performed using a kit to detect the Staphylococcal toxin by reversed passive latex agglutination (PVL-RPLA ''Seiken,'' Denka Seiken Co., LTD). SA isolates were tested for antibiotic susceptibility using disk diffusion at the time of isolation. Multi-antibiotic resistance was defined as resistance to at least 3 classes of antibiotics. Results: Of the 20 isolates, 15 were multi-antibiotic resistant and PVL-negative consistent with HA, and 1 was not multi-antibiotic resistant and PVL-positive, consistent with CA. Two isolates tested positive for PVL with one demonstrating both methicillin and fluoroquinolone (FQ) resistance. Of the 18 PVL-negative SA isolates, 15 (83%) were multi-antibiotic resistant (12 methicillin-resistant SA, 14 FQ resistant). Conclusions: Our results reject the hypothesis that SA isolated from endophthalmitis is consistent with CA sources due to the lack of the PVL toxin and multiple resistant patterns of the SA. PVL does not appear to be a key virulence factor for the development of SA endophthalmitis.
A combination of laser photocoagulation and anti-VEGF theraphy can be effective in the treatment of macular exudation and edema from a retinal angioma.
Preterm (PT) infants are routinely screened for retinopathy of prematurity (ROP). After ROP screening exams, PT infants are at risk for adverse events (AEs), including apnea and bradycardia (ABD), respiratory decompensation, infection, and gastrointestinal complications. Music therapy (MT) has been shown to improve overall physiologic stability in PT infants in the neonatal intensive care unit (NICU). In this case series, a board-certified music therapist used a music therapy protocol during 47 ROP screening exams. The study’s purpose was to explore the potential effects of NICU MT on AEs linked to ROP screening. No infant had any respiratory decompensation, new infection, or other complications. The rate of ABD after screening exams was low. MT during ROP screening appears safe and feasible. We hypothesize that MT might prevent ABD associated with ROP screening, a theory that could be effectively studied in a randomized controlled trial.
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