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In an effort to assist medical researchers and professionals in accessing information necessary for their work, the A1 Lab at the University of Arizona is investigating the use of a natural language processing (NLP) technique called noun phrasing. The goal of this research is to determine whether noun phrasing could be a viable technique to include in medical information retrieval applications. Four noun phrase generation tools were evaluated as to their ability to isolate noun phrases from medical journal abstracts. Tests were conducted using the National Cancer Institute's CANCERLIT database. The NLP tools evaluated were Massachusetts Institute of Technology's (MIT's) Chopper, The University of Arizona's Automatic Indexer, Lingsoft's NPtool, and The University of Arizona's AZ Noun Phraser. In addition, the National Library of Medicine's SPECIALIST Lexicon was incorporated into two versions of the AZ Noun Phraser to be evaluated against the other tools as well as a nonaugmented version of the AZ Noun Phraser. Using the metrics relative subject recall and precision, our results show that, with the exception of Chopper, the phrasing tools were fairly comparable in recall and precision. It was also shown that augmenting the AZ Noun Phraser by including the SPECIALIST Lexicon from the National Library of Medicine resulted in improved recall and precision.

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0 This research examined the applicability of using a neural network approach to analyze population pharmacokinetic data. Such data were collected retrospectively from pediatric patients who had received tobramycin for the treatment of bacterial infection. The information collected included patient-related demographic variables (age, weight, gender, and other underlying illness), the individual's dosing regimens (dose and dosing interval), time of blood drawn, and the resulting tobramycin concentration. Neural networks were trained with this information to capture the relationships between the plasma tobramycin levels and the following factors: patient-related demographic factors, dosing regimens, and time of blood drawn. The data were also analyzed using a standard population pharmacokinetic modeling program, NON-MEM. The observed vs predicted concentration relationships obtained from the neural network approach were similar to those from NONMEM. The residuals of the predictions from neural network analyses showed a positive correlation with that from NONMEM. Average absolute errors were 33.9 and 37.3% for neural networks and 39.9% for NONMEM. Average prediction errors were found to be 2.59 and −5.01% for neural networks and 17.7% for NONMEM. We concluded that neural networks were capable of capturing the relationships between plasma drug levels and patient-related prognostic factors from routinely collected sparse withinpatient pharmacokinetic data. Neural networks can therefore be considered to have potential to become a useful analytical tool for population pharmacokinetic data analysis.