Gastroesophageal reflux disease is common in adult eosinophilic esophagitis patients. Dysphagia improves and esophageal eosinophilic infiltration decreases with either treatment. There was no difference in degree of improvement in dysphagia or eosinophil infiltration in patients treated with either topical fluticasone or oral esomeprazole. GERD may be important in the pathogenesis of adult EoE.

SUMMARY BackgroundEosinophilic oesophagitis (EoO) may be a common finding in adults presenting with dysphagia.

We present a fully sampled C 18 O (1-0) map towards the southern giant molecular cloud (GMC) associated with the H II region RCW 106, and use it in combination with previous 13 CO (1-0) mapping to estimate the gas column density as a function of position and velocity. We find localized regions of significant 13 CO optical depth in the northern part of the cloud, with several of the high-opacity clouds in this region likely associated with a limb-brightened shell around the H II region G333.6−0.2. Optical depth corrections broaden the distribution of column densities in the cloud, yielding a lognormal distribution as predicted by simulations of turbulence. Decomposing the 13 CO and C 18 O data cubes into clumps, we find relatively weak correlations between size and linewidth, and a more sensitive dependence of luminosity on size than would be predicted by a constant average column density. The clump mass spectrum has a slope near −1.7, consistent with previous studies. The most massive clumps appear to have gravitational binding energies well in excess of virial equilibrium; we discuss possible explanations, which include magnetic support and neglect of time-varying surface terms in the virial theorem. Unlike molecular clouds as a whole, the clumps within the RCW 106 GMC, while elongated, appear to show random orientations with respect to the Galactic plane.

Eosinophilic Esophagitis (EE) is an emerging cause of esophageal food impaction (EFI) not accounted for in previous studies. We sought to determine the causes of EFI in a recent cohort with recognition of EE. A retrospective chart review of all patients with EFI during the past 5 years was performed. Etiology was determined by endoscopy report, pathology results, and follow-up studies. A total of 85 EFIs occurred, in 79 patients (55 men, 30 women, age 18-100). The most common etiologies of EFI were Schatzki's ring (n = 18), peptic stricture (n = 18), EE (n = 9), esophagitis (n = 9), and no underlying diagnosis (n = 20). EE was significantly more frequent in men (P < .025) and those <50 years old (P < .025). There was a significant difference in the age at which men (median age = 44) and women (median age = 71) present with EFI (P < .001). The etiology of EFI differs significantly by age and gender. This information may be useful in evaluation and management of EFI.

No abstract