Both contrast agents, Levovist and DD-723, produced platelet activation and structural change in the rat hepatic cells, but only the microbubbles of DD-723 were taken up by the Kupffer cells and a few hepatocytes.
Case 1, Borrmann's type 2 carcinoma detected by endoscopy in the body of the stomach of a 59-year-old man. Total gastrectomy with splenectomy was performed. Histologic examination revealed a poorly differentiated adenocarcinoma with marked venous invasion. Follow-up ultrasonography showed the tumor thrombi in the splenic vein to be progressively distended to the superior mesenteric vein and the peripheral branches of the intrahepatic portal vein.Case 2, Borrmann's type 4 carcinoma clinically diagnosed in a 77-year-old man. Ultrasonography detected tumor thrombi in the left gastric, splenic, and extrahepatic portal veins associated with cavernous transformation at the porta hepatis.Case 3, Moderately differentiated adenocarcinoma extending from the cardia to the middle body of the stomach diagnosed in a 69-year-old man. Ultrasonography detected a solid mass at the splenomesenteric confluence. Values of ot -fetoprotein (AFP) and protein induced by vitamin K antagonist-]I (PIVKA-]I) were markedly elevated.Recent progress in imaging technology will increase the probability of encountering the condition reported here. Color Doppler ultrasonography is useful for diagnosing portal thrombus and provides a great deal of information noninvasively.
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