Yogaratnakara (1676 AD) is one among the most renowned literatures in Ayurveda. It's a compilation book from different classical texts available at that time period ranging from ancient period to later part of the 17 th century AD. One of the specialties of this book is compilation of single drug in different form specific to different disease conditions. To simplify the preparation and treatment author has focused on the use of ekala dravya in every chikitsa-prakarana. This work has been taken up to have a compilation of data of single drug in the given condition. The purpose of this study is to enlist the ekala dravya prayoga (single drug uses) mentioned for various conditions and diseases based on Yogaratnakara purvardha. Detail review of purvardha khanda of Yogaratnakara was carried out based on Hindi Commentary, Vidyotini teeka by Vaidya Sastri Laksmipati and edited by Sastri Brahmasankar, published by Chaukhamba publication. Single drug uses mentioned in chikitsa prakarana of each and every disease have been noted. Botanical identification and use of plant parts in some cases were referred from relevant books. Total 125 single drug uses have been noted from yogaratnakara purvardha.
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