Background: Chronic neck pain is a common musculoskeletal dysfunction, and Manual Therapy is one of the effective treatment modalities, but underlying mechanisms of action are unclear. The study's purpose was to investigate the short-term effect of mobilization-manipulations on patient's symptoms and to detect changes in the concentration of inflammatory biomarker interleukin-1b. Methods: Twenty-two patients aged 20-50 years with chronic neck pain, randomly assigned into two groups. The study group received nine sessions of a three-week Manual Therapy intervention. The control group received SHAM Manual Therapy of the same dosage. Pain and functionality measures conducted before and after the intervention via NPRS and NDI scales, respectively. Blood samples collected at baseline, after the first session and post-intervention, detecting IL-1β concentration, using the corresponding ELISA kit. Mixed ANOVA statistical analysis implemented for differences in the GROUP-TIME factors. Results: There was a significant statistical interaction between factors and significant main effects on pain, functionality, and IL-1β (p <.05). IL-1β was statistically significant reduced (p <.05) at second measurement for the study group, but not significantly reduced (p> .05) between second and final measurement. No statistical significance was found for the control group on any of the dependent variables across measures.
Conclusion:Patients with chronic mechanical pain showed significant pain and functionality improvement after manual therapy application. The underlying mechanism of action seems to relate with a reduced IL-1b concentration of reinforcing future research at relevant pain biomarkers.
Background: It is well known that Iliotibial band syndrome (ITBS) is the most frequent overuse injury in recreational runners. Given the fact that there are no clear guidelines on the optimal conservative treatment approach regarding ITBS rehabilitation, manual therapy effect by a functional joint mobilization is still unknown. The purpose of the study was to investigate whether implementation of mobilization-with-movement (MWM) and auto-mobilization had a significant short-term improvement in pain and functionality of recreational runners with ITBS.Methods: Participants: thirty ITBS patients, were randomly assigned into two groups. Design and Settings: One group pre-test /post-test with the control group. Interventions: Runners on the treatment group followed an MWM protocol of six sessions with an additive program of auto-MWM, while the control group received a SHAM form of MWM. Outcome measurements: Pain and functionality were measured at baseline and post-treatment, via Numeric Pain Rating scale and Lower Extremity Functional Scale respectively. Mixed-ANOVA test detected possible differences among treatment phases and between groups, but also interactions among factors.
Result:The present findings revealed significant interactions between factors and significant main effects of each TIME and GROUP factors on pain and functionality. MWM-treatment group showed significant improvement in post-intervention NPRT and LEFS scores, compared to baseline scores (p<.001). SHAM-MWM group exhibited no significant differences on post-NPRT and LEFS scores, compared to baseline (p>.001). Differences between groups were significant in post-treatment scores (p<.001).
Conclusion:Our findings suggest that MWM and auto-MWM are a significant treatment approach, improving pain and functionality in recreational runners suffering from ITBS.
On the field of non-pharmaceutical prevention and treatment of postmenopausal women's bone mineral density (BMD), exercise is undoubtedly a fundamental component, having a beneficial effect on a number of health parameters.Resistance training seems to adequately stimuli the musculoskeletal system on the physiology of bone tissue response. The study's objective was to analyze the most recent research on the clinical uses of resistance training in therapy regimens for postmenopausal women while analyzing and criticizing the data in light of the growing research heterogeneity. Data collection was carried out through electronic databases PubMed. Forty related metaanalysis and systematic reviews published on the last five years, were included as the sample for analysis. Studies regarding pharmaceutical and/or diet intervention were excluded. Results demonstrated that resistance training, either alone or in combination with other forms of exercise, significantly improved postmenopausal women's BMD. The workout criterion that suggests acceptable future study designs and exact research technique is intensity, which appears to be the most intriguing.
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