Environmental pollution with ecotoxicants makes humanity rethink its attitude to the world around it and accept the concept of the need to protect people and animals living on our planet. This paper presents the results of experimental studies of substances of natural origin for the selection of the most promising ones in order to create a multifunctional means of protecting farm animals in areas of anthropogenic pollution. In vitro experiments on lethally irradiated lymphocytes of the peripheral blood of animals, the radioprotective properties of phytogenic preparations were evaluated, and a three-component radioprotective composition was created. On lethally irradiated laboratory animals, the radioprotective activity of various compositions constructed from microbial biomasses and metabolic products of E. coli “PL-6”, B. bifidum 1 bacterial strains, phyto- and zoo drugs preparations radiomodified at a dose of 4 kGy was tested. From the metabolites of the radiomodified bacterial strain B. bifidum 1 (R6), the phytopreparation “Turmeric” and the biologically active feed additive “Vita-Force M”, the phytozoic microbial preparation FZMP was designed and tested on laboratory animals, which provided protection from radiation death to 80% of lethally irradiated laboratory animals, with 100% death of rats in the irradiation control group.
Currently, despite the improvement of radiation safety measures, there is a risk of increasing frequency of radiation accidents and various disasters accompanied by explosions, fires and emissions of radionuclides. Emergencies (emergencies) of peacetime and wartime, especially accidents at radiation-hazardous facilities, including nuclear power plants, carry the danger not only of irradiation of people, but also at the same time thermal burns, mechanical injuries, chemical poisoning by harmful gorenje products, as well as other lesions. Experimental modeling of acute radiation and burn disease was carried out both separately and in combination. It was found that external total gamma irradiation of white rats at a dose of 7.5 Gy causes severe radiation sickness with characteristic clinical signs and high mortality of irradiated animals. A heat stroke simulation was performed by applying a metal plate heated to 190°C with an exposure time of 5 and 8 seconds. It turned out that the degree of burn depends on the time of contact with the surface of the body: its application within 5 seconds caused a burn of the III-A degree, an 8-second exposure of the IIIB degree, which was confirmed by the timing of formation, rejection of eshar and complete healing of the thermal lesion. The aggravating effect of ionizing radiation on the course and outcome of combined radiation-thermal pathology is demonstrated.
Considering that in radiation biocenoses in animals under the influence of ionizing radiation, various biological changes occur, in the form of stimulation or suppression of the development of parasites in the host organism, as well as post-radiation changes in the host organism. We have car-ried out these studies, the purpose of which was to determine the infestation of laboratory animals by helminths, to study the effect of parasites on the course of acute radiation sickness and to assess the modifying effect of the «OS» drug on animals with combined radiation-biological damage.
in several series of experiments, the preventive and therapeutic properties of preparations based on strains of E. coli "PL-6" microorganisms and products of their metabolism with the addition of natural hydroxides and aluminum hydrosilicates in acute radiation sickness of animals were studied. It was found that microbial preparations and their metabolites have radioprotective properties, so they can be used in creating radioprotective compositions.
The result of research, conducted using our immuno-chemical testing system (Reaction of Indirect Hemaglutination) shows that application of radiation exposure to farming and agro products in dosages needed for prolongation of their storage lifetime, for prevention of rotting and germination or for decontamination of feed-stuff from natural microflora and insects; leads to increase in radiotoxins contents thereof with maximums reached on 7-15 days. Besides, traces of radiotoxins in reaction of indirect hemaglutination depend on type of product, radiation dosage and time of product storage after radiation treatment.
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