Feline polycystic kidney disease (PKD), an inherited autosomal dominant disease, has been reported to occur mostly in Persian or Persian related cats, and to be associated with a mutation
from C to A at position 10063 in exon 29 of the feline
PKD1
gene (
PKD1
mutation). Many clinical cases have been recognized in Japan, but the mutation rate
in cats has not been reported. The objective of this study was to determine epidemiological characteristics and clinical features in cats with the
PKD1
mutation. Referring
veterinarians sent blood samples of 377 cats for the
PKD1
gene evaluation. The blood samples were from 159 cats with renal cysts confirmed by ultrasonography, 60 cats
without renal cysts, and 158 cats that did not undergo ultrasonography. In total, 150 cats carried the
PKD1
mutation and the signalment, site and number of renal cysts, and
results of blood test were evaluated in cats with the
PKD1
mutation. The breeds with the highest rate of the
PKD1
mutation were Persian (46%), Scottish Fold
(54%) and American Shorthair cats (47%). However, mixed breed cats also showed high rates of the
PKD1
mutation. Of cats with the mutation, the incidence of high plasma
creatinine (≥1.6 mg/d
l
) was greater in cats ≥3 years old, although a few cats ≥9 years of age had low plasma creatinine (<1.6 mg/d
l
). The coincidence of
renal and hepatic cysts was 12.6%, with the high prevalence in Persian cats (31%).
In September 2012, five Bolivian squirrel monkeys housed in a zoological park died within sequential several days without obvious clinical signs. In a
necrospy, one monkey presented swelling of the kidney with multifocal white nodules in the parenchyma, and other two had pulmonary congestion.
Histopathologically, multifocal bacterial colonies of gram-negative coccobacillus were found in the sinusoid of the liver in all monkeys examined (Nos.1−4).
Additionally, purulent pyelonephritis, pneumonia and disseminated small bacterial colonies in blood vessels were observed. Immunohistochemically, the bacterial
colonies from two monkeys were positive for P. multocida capsular serotype D. Based on these findings, these monkeys were diagnosed as
septicemia caused by acute P. multocida infection.
ABSTRACT. Sheep were inoculated with high tax coded pBLV-IF (H group, Nos.1-5) of bovine leukemia virus (BLV), wild tax coded pBLV-IF (W group, Nos. 6-11), or control plasmid (C group,. During the observation period (4 to 46 months), 5 of 5 cases in H group and 3 of 6 cases (Nos. 6, 7, 9) in W group became positive for gp 51. Only 1 case in H group became leukemic, and one case each of H and W groups developed lymphoma. In No. 3, lesions were found in multiple organs including the lymph nodes, gastrointestinal tract following abomasum, and heart. In No. 6, lesions of lymphoma were found only in the jejunum and heart. Morphologically, small to middle-sized lymphocytic neoplastic (NP) cells were found in both cases, but lymphoblastic NP cells were found only in No. 3. By immunohistochemical examination, the phenotypes of NP cells were determined as CD1 -, CD4 -, CD5 --, CD8α -, sIgM + , λ light chain + , B-B4 + , MHC class II + in both case. The results of this study indicate that inoculation of pBLV-IF can induce lymphocytic and lymphoblastic leukemia/lymphoma in sheep. Additionally, it is suggested that the expression rate of tax gene is not associated with the development of leukemia/lymphoma in sheep experimentally inoculated with pBLV-IF.
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