Genomic DNAs containing the gene encoding apolipoprotein A-I (apoA-1) from four strains of mice and three strains of rats have been sequenced. Some peculiar repetitive sequences were found in the third intron of apoA-1 of the murine species. The striking features include regular tandem repeats of C(A)4 and C(A)6 in mice and long A-tracts in rats. Not completely identical but very similar motifs were found in mice or rats belonging to the same species while repetitive elements from different species show some variation from their speciesspecific consensus sequences. These repetitive motifs are very similar to the sequences flanking human Alu and rodent B 1 repetitive elements, although no evidence for the existence of Alu or B 1 was found near the peculiar repetitive DNA sequences in apoA-1 gene.
BIOCHEMISTRY and MOLECULAR BIOLOGY INTERNATIONALMice and rats are useful experimental models for studying the genetic factors that may be
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