The ExoCounter system exhibits high performance in the direct detection of exosomes in cell culture and human sera. This method may enable reliable analysis of liquid biopsies.
The detection of biomarkers in body fluids is useful for the early detection of diseases or preventive medical care. Various types of equipment that detect biomarkers have been developed and used for various occasions. It is expected that further improvement of the detection sensitivity of biomarkers will enable the extension for their applications to various diseases. In this paper, we propose a new biomarker sensing system with higher sensitivity. In the system, by combining optical disc technologies and nanobead technologies, we developed a new sensing method. Target biomarkers are specifically immobilized onto the optical disc surface through an antigen-antibody reaction, then the nanobeads are immobilized on top of the biomarkers. Since the biomarkers and beads bind to each other one-on-one, the number of target biomarkers can be measured by counting the number of nanobeads using an optical pickup. The most significant advantage of this method is that measurement can be carried out in a fully digital scheme, in contrast to current sensing systems which measure light intensity in an analog scheme.
Super-resolution (SR) effects of a thermo-chromic organic dye
mask layer are
investigated for a rewritable disk with a Ag–In–Sb–Te phase-change
recording layer.
Clear SR effects were recognized in both linear and radial directions
in the rewritable
disk, corresponding to a capacity of 10.3 GB in a 120 mm disk. A
carrier-to-noise ratio
over 35 dB was obtained at a short mark length of
0.2 µm. Crescent-shaped marks,
which are typically recognized in high-density magneto-optical (MO)
media, were
observed in the phase-change recording layer. The SR effects mainly
operate on the
reading process, resulting from a large non-linear transmittance
change in the organic dye.
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