Summary: This study demonstrated the time-dependent changes in postmortem responses of isolated human mid dle cerebral artery strips to vasodilators, The relaxation induced by prostaglandin (PG) 12 or nitroglycerin re mained stable for 24 h postmortem. In arterial strips precontracted with PGF2a, substance P and bradykinin both elicited relaxation that was almost completely abol ished by removal of the endothelium. The endothelium dependent response to both peptides was significantly de graded in strips obtained> 12 h postmortem. These reExperimental methods applied to isolated vessel preparations have been useful in the analysis of ves sel physiology and pathology. However, evidence of interspecies variation in the responsiveness of blood vessels to vasoactive substances has emerged, casting doubt on the applicability of ani mal data to humans (Toda, 1990a,b). On the other hand, the use of postmortem human cerebral ves sels for experiments suffers from doubts about pos sible changes in vascular function after death.Few laboratory studies have attempted to char acterize the functional changes in postmortem hu man cerebral arteries (Starling et ai., 1975; Toda et ai., 1985; Verheggen et ai., 1991). These studies suggested that the contractile responses of human cerebral arteries were maintained for up to 24 h
A transcallosal interforniceal approach was used for treatment of a posteriorly projecting high basilar bifurcation aneurysm with a neck located 30 mm above the posterior clinoid process. The aneurysm was successfully clipped via the third ventricle with minimal neurological deficits. This approach appears to be appropriate for basilar bifurcation aneurysms located more than 20 mm above the posterior clinoid process when the fundus projects posteriorly, and permits direct visualization of the aneurysmal neck and vital perforators with minimal brain retraction.
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