Organ-specific stem cells can be identified by the side population (SP) phenotype, which is defined by the property to effectively exclude the Hoechst 33342 dye. The ATP-binding cassette transporter ABCG2/ BCRP1 mediates the SP phenotype. Because hepatic oval cells possess several characteristics of stem cells, we examined whether they have the SP phenotype using the 2-acetylaminofluorene/partial hepatectomy (PH) model. Fluorescence-activated cell sorting analysis showed that a population of non-parenchymal cells containing oval cells, prepared on day 7 after PH, carried a significant number of SP cells, whereas that of non-parenchymal cells without oval cells, prepared on day 0 after PH, did not. Northern blot analysis using total liver RNA obtained on various days after PH showed that the expression of ABCG2/BCRP1 mRNA increased after PH, reaching the highest level on day 7, and then gradually decreased. This pattern of changes in the ABCG2/BCRP1 mRNA level was well correlated to that in the number of oval cells. Hepatocytes proliferate after liver damage such as partial hepatectomy (PH), resulting in regeneration of the liver.
The mean interaural ratio was 16.5+/-12.1% in the control group, thus the normal range was <40.7%. Abnormal results were not found in any subject in the non-disequilibrium group but were found in 13 patients (54.0%) in the disequilibrium group (p<0.001). The ear with COM showed lower responses than the intact ear in all subjects with abnormal results.
OBJECTIVE:: To study the immediate efficacy of the canalith repositioning procedure (CRP) in the treatment of benign paroxysmal positional vertigo. PATIENTS:: Thirty-four patients with benign paroxysmal positional vertigo. INTERVENTION:: Eighteen patients were treated with CRP (CRP group); 16 control patients did not receive CRP treatment (non-CRP group). MAIN OUTCOME MEASURES: We compared the success rates of the CRP and non-CRP groups. The treatment was considered successful if it prevented vertigo and dizziness. Patients were evaluated 3 times: immediately posttreatment (the day after the first visit), in the short term (1 wk after treatment), and in the midterm (1 mo after treatment) RESULTS:: Successful outcomes occurred in 12 patients (67%) from the CRP group and in 1 patient (6%) from the non-CRP group as immediate results (p < 0.001), 13 (72%) and 4 patients (25%) in the short term, respectively, (p = 0.007), and 16 (89%) and 14 patients (88%) in the midterm, respectively, (p > 0.05). Among patients in the CRP group who did not report immediate success, 1 patient (6%) reported success after 1 week (short term), and 4 patients (67%) had successful outcomes after 1 month (midterm). CONCLUSION:: The immediate efficacy of CRP supported the canalolithiasis theory. The prognosis of patients with immediate unsuccessful results with CRP was somewhat worse than that for patients without CRP treatment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.