Waon therapy is safe, improves clinical symptoms and cardiac function, and decreases cardiac size in CHF patients. Waon therapy is an innovative and promising therapy for patients with CHF.

HBOT performed 3 hrs after lipopolysaccharide challenge alleviates intestinal barrier dysfunction and improves survival rates. Herein, we propose one possible mechanism for these beneficial effects: HBOT can modify the nuclear factor-kappaB activation in the intestinal mucosa and attenuate the sequential nitric oxide overproduction and myeloperoxidase activation. Consequently, bacterial translocation could be potentially decreased. We believe that the present study should lead to an improved understanding of HBOT's potential role in sepsis.

Recent studies have shown that hyperbaric oxygen therapy (HBOT) reduces neutrophil endothelial adherence in venules and also blocks the progressive arteriolar vasoconstriction associated with ischemia-reperfusion (I-R) injury in the extremities and the brain. In order to elucidate the effects of HBOT after I-R in digestive organs, particularly in the liver, we evaluated the following: 1) the relationship between timing of HBOT and tissue damage; and 2) HBOT's effects on neutrophil sequestration. Using a hepatic I-R (45 minute) model in male rats, survival rate, liver tissue damage, and neutrophil accumulation within the sinusoids in the HBOT-treated group (Group H) were compared to those in the nontreated group (Group C). For the HBOT-treated group, HBOT was administered as 100% oxygen, at 2.5 atm absolute, for 60 minutes. When HBOT was given 30 minute after I-R, the survival rate was much better in Group H than in Group C. HBOT performed within 3 hours of I-R markedly suppressed increases in the malondialdehyde level in tissues of the liver and lessened the congestion in the sinusoids. In addition, HBOT just after I-R caused decreased number of cells stained by the naphthol AS-D chloroacetate esterase infiltrating into the sinusoids. HBOT 3 hours after reperfusion, however, showed no clear effects upon neutrophil sequestration compared to Group C. These results indicate that HBOT performed within 3 hours of I-R alleviates hepatic dysfunction and improves the survival rate after I-R. Herein, we propose 1 possible mechanism for these beneficial effects: early HBOT given before neutrophil-mediated injury phase may suppress the accumulation of neutrophils after I-R. In conclusion, we believe that the present study should lead to an improved under- W arm hepatic ischemia-reperfusion (I-R) is characterized by circulatory and metabolic disruptions, liver dysfunction, and tissue damage. Recent advances in the research regarding the basic mechanisms of I-R showed the significance of Kupffer cells and neutrophils. 1 Kupffer cells play a central role as the initial cytotoxic cell type and as a source of many proinflammatory mediators such as tumor necrosis factor-␣ (TNF-␣) and interleukin (IL)-6. 2-6 Subsequently, neutrophils are activated and migrate into the liver. Researchers have pointed out that accumulated neutrophils contribute to the injury several hours after the initiation of reperfusion. 7 In fact, antibodies against adhesion molecules such as Mac-1 (cluster of differentiation molecule 11b/18) or intracellular adhesion molecule-1 (ICAM-1) are still beneficial, ever if administered during the Kupffer cell-mediated injury phase. [7][8][9][10][11][12] Hyperbaric oxygen therapy (HBOT) is a specific type of oxygen administration that aims to improve numerous kinds of hypoxic disorders by increasing the amount of dissolved oxygen within the blood. 13 Recent studies have shown that HBOT reduced neutrophil endothelial adherence in venules and also blocked the progressive arteriolar vasoconstriction associated with repe...

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The stature of children with moderate-to-severe CP can be estimated from their tibial lengths, regardless of the presence of joint contracture or scoliosis. The tibial length may be a proxy for estimating stature during the growth assessment of children with moderate-to-severe CP.