It has been reported that many tau sites in neurofibrillary tangles (NFT) are abnormally phosphorylated. We investigated the phosphorylation of tau in the hippocampus of nondemented patients and Alzheimer''s disease patients by immunostaining with five site-specific antibodies against phosphorylated tau. In the pretangle stage, tau in neuropil threads was phosphorylated at serines 199, 202 and 409, numbered according to the longest human tau isoform, whereas tau in some neuronal soma was phosphorylated at serines 199, 202, 409 and 422. Tau at the stage of NFT was phosphorylated at serine 396 and threonine 231 in addition to serines 199, 202, 409 and 422. In the advanced stage, tau in ghost tangles was phosphorylated mainly at serine 396. These results suggest that the phosphorylation of each site in tau differs among the maturing stages of neurofibrillary change and that abnormal phosphorylation of tau in the neuronal soma occurs at 199, 202, 409 and 422 earlier than at threonine 231 and serine 396.

Background: This paper analyzes ownership and control of productive resources by gender as determined by culture. This is premised on the fact that past researchers have isolated gender and productive resources on one hand and gender and culture on the other. In this paper, the novelty is the exploration of the interplay among culture, gender and productive resources. Using a descriptive quantitative research design, a simple random sampling was used to select 100 households from a sampling frame of 200 households generated through house listing in three villages from Patigi Local Government Area of Kwara State. Data were collected with a structured questionnaire covering ownership, and decision making on selected productive resources and analyzed using Frequency counts, percentages and Chi-square test statistics based on the fact that the variables are categorical. Gender and ownership as well as decision making were cross-tabulated and then layered with culture as a third variable. Results:The results were disaggregated along Nupe and Yoruba culture as well as along gender lines for the selected productive resources covered in this paper. Men predominate in ownership of productive resources among Yoruba than Nupe culture. Women from Nupe culture had higher distribution of ownership in the productive resources than men particularly land, small livestock and non-mechanized farm equipment. The results further show higher proportion of ownership of productive resources among men in Yoruba culture. Women in Nupe culture had greater proportion of ownership of productive resources than Yoruba women. Males make decision to sell all productive resources except small livestock and also make decision in almost all the farming activities listed except when and who will take crop to the market in both Nupe and Yoruba cultures. Conclusion:Culture has a stronger influence on women's access and control of productive resources than the mere biological differentiation of gender into male and female. There is a strong cultural influence among Nupe and Yoruba women as a result of the interplay of gender, ownership and decision making and culture on selected productive resources.

Granulovacuolar degeneration (GVD) and neurofibrillary tangles (NFT) are neuropathological features in Alzheimer's disease (AD). The molecular mechanism of GVD formation remains unknown. Recent immunohistochemical investigations suggested a potential link of NFT to GVD formation. Enzyme histochemical studies and electronmicroscopic findings suggested that GVD is formed through lysosomal autophagy of intraneuronal substances. We recently demonstrated that in non-demented cases NFT was phosphorylated at serines 199, 202 and 422 in paired helical filament (PHF)-tau more than in serine 396, while NFT in AD cases was similarly phosphorylated at these four sites in tau. In this study, we demonstrated immunohistochemically a similar phosphorylation state of tau in GVD granules to that in NFT in both non-demented cases and AD patients by using a mouse monoclonal anti-tau antibody and three phosphorylation site-specific antibodies for PHF-tau, indicating that GVD granules and NFT are composed of similar phosphorylated-tau. However, we could not detect PHF structures within any GVD using electronmicroscopy, indicating that PHF itself is not phagocytized by lysosomes during GVD formation. Therefore, the source of GVD granules might be phosphorylated pre-PHF-tau.

A family with X-linked hydrocephalus with normal cerebrospinal fluid (CSF) pressure and in which three brothers and a grandson of case 1, a proband, were affected is reported. The symptoms at onset were epileptic attacks that started in adulthood in the three brothers and at the age of 6 years in the grandson. In the three brothers, from 10 to 27 years after the onset of epileptic episodes, disorganization of intelligence and psychiatric deterioration were gradually noticed by their families. At the same time, they showed occasional urinary incontinence. Brain computed tomography (CT) scans revealed dilatation of the ventricular systems. Based on the results of the measurement of CSF pressure and radioactive-iodinated human serum albumin (RISA)-cysternography, two of the brothers were diagnosed as having normal pressure hydrocephalus (NPH), and they were treated neurosurgically. However, no obvious improvement in clinical symptoms was observed. Although the grandson had shown normal psychomotor development during his early childhood, temporal epilepsy and temper tantrums started at the age of 6 years. Computed tomography-scanning revealed dilatation of the ventricular system similar to the other three cases at the age of 8 years. With the diagnosis of NPH, the patient underwent a shunt operation, which resulted in no obvious effects. As it is reasonable to surmise that the pathological gene would have been transferred via the daughter of the proband to the grandson, it is suggested that the inheritance manner might be X-linked recessive. The cases presented here are different from the cases of hydrocephalus due to stenosis of the aqueduct Sylvius (HSAS) and other types of X-linked hydrocephalus reported previously in terms of the age of onset, course, symptoms, and CT findings. Thus, it is suggested that the present cases might be a new type of Xlinked hydrocephalus.

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