A new
method to synthesize γ-carboline derivatives has been
developed starting from 3,5-dibromo-4-pyridinamine by monoarylation
using the Suzuki–Miyaura cross-coupling reaction followed by
the base-mediated ring closure to pyrrole formation. Synthesis of
a series of γ-carboline derivations from the 4-brominated γ-carboline 4a has been achieved by employing various coupling reactions
and N-alkylations. This method has been applied for the synthesis
of the antimalarial and anticancer natural product isocryptolepine.
The photophysical properties of novel γ-carboline derivations
are also reported.
Mit dem Ziel, die Annahme zu beweisen, daß die Strukturanalogen von D‐Alanyl‐D‐alanin, die an der Biosynthese von Zellwandpeptiden beteiligt sind, das Wachstum von Mikroorganismen verhindern, wurde die Titelverbindung dargestellt.
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