Sr isotope stratigraphy provides a new age model for the fi rst complete section drilled through a deep-water coral mound. The 155-m-long section from Challenger Mound in the Porcupine Seabight, southwest of Ireland, is on Miocene siliciclastics and consists entirely of sediments bearing well-preserved cold-water coral Lophelia pertusa. The 87 Sr/ 86 Sr values of 28 coral specimens from the mound show an upward-increasing trend, correspond to ages from 2.6 to 0.5 Ma, and identify a signifi cant hiatus from ca. 1.7 to 1.0 Ma at 23.6 m below seafl oor. The age of the basal mound sediments coincides with the intensifi cation of Northern Hemisphere glaciations that set up the modern stratifi cation of the northeast Atlantic and enabled coral growth. Mound growth persisted throughout glacial-interglacial fl uctuations, reached a maximum rate (24 cm/k.y.) ca. 2.0 Ma, and ceased at 1.7 Ma. Unlike other buried mounds in Porcupine Seabight, Challenger Mound was only partly covered during its growth interruption, and growth restarted ca. 1.0 Ma.

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[1] Recent deep-ocean exploration has revealed unexpectedly widespread and diverse coral ecosystems in deep water on continental shelves, slopes, seamounts, and ridge systems around the world. Origin and growth history of these cold-water coral mounds are poorly known, owing to a lack of complete stratigraphic sections through them. Here we show high-resolution oxygen isotope records of planktic foraminifers from the base to the top of Challenger Mound, southwest of Ireland, which was drilled during Integrated Ocean Drilling Program Expedition 307. Challenger Mound began to grow during isotope stage 92 (2.24 million years ago (Ma)), immediately after the onset of Northern Hemisphere glaciation and the initiation of modern stratification in the northeast Atlantic. Mound initiation was likely due to reintroduction of Mediterranean Outflow Water (MOW) and ensuing development of a density gradient with overlying northeastern Atlantic water (NEAW), where organic matter was prone to be stagnated and fueled the coral ecosystem. Coral growth continued for 11 glacialinterglacial cycles until isotopic stage 72 (1.82 Ma) with glacial siliciclastic input from the continental margin. After a long hiatus that separates the lower mound and the upper mound, coral growth restored for a short time in isotope stages 19-18 (0.8-0.7 Ma) in which sediments were either eroded or not deposited during a full glacial stage. The development pattern of the water mass interface between MOW and NEAW might have changed, because of the fluctuations of the MOW production which is responsible for the amplitude in ice volume oscillations from the low-amplitude 41 ka cycles for the lower mound to the high-amplitude 100 ka cycles for the upper mound. The average sedimentation and CaCO 3 production rates of the lower mound were evaluated 27 cm/ka and 31.1 g/cm 2 /ka, respectively.

SummaryThe ErbB family of receptor tyrosine kinases comprises four members: epidermal growth factor receptor (EGFR)/ErbB1, HER2/ErbB2, ErbB3 and ErbB4, and plays roles in signal transduction at the plasma membrane upon ligand stimulation. Stimulation with neuregulin-1 (NRG-1) cleaves ErbB4 and releases the ErbB4 intracellular domain (4ICD) that translocates into the nucleus to control gene expression. However, little is known about the regulation of 4ICD nuclear signaling through tyrosine phosphorylation. We show here that 4ICD nuclear signaling is antagonized by EGF-induced c-Src activation through EGFR. Generation of 4ICD by NRG-1 leads to increased levels of trimethylated histone H3 on lysine 9 (H3K9me3) in a manner dependent on the nuclear accumulation of 4ICD and its tyrosine kinase activity. Once EGF activates c-Src downstream of EGFR concomitantly with NRG-1-induced ErbB4 activation, c-Src associates with phospho-Tyr950 and phospho-Tyr1056 on 4ICD, thereby decreasing nuclear accumulation of 4ICD and inhibiting an increase of H3K9me3 levels. Moreover, 4ICD-induced transcriptional repression of the human telomerase reverse transcriptase (hTERT) is inhibited by EGF-EGFR-Src signaling. Thus, our findings reveal c-Src-mediated inhibitory regulation of ErbB4 nuclear signaling upon EGFR activation.

Background: Lyn tyrosine kinase is anchored to the plasma membrane. Results: Cell detachment changes Lyn distribution from the low density to the high density membrane fractions and activates Lyn through decreased membrane cholesterol levels. Conclusion: Cell detachment-induced Lyn activation plays a role in survival of suspension cells. Significance: Our results provide novel insight into signal transduction upon cell detachment.

The discovery of mounds and reefs hosting cold‐water coral ecosystems along the northeastern Atlantic continental margins has propelled a vigorous effort over the past decade to study the distribution of the mounds, surface sediments, the ecosystems they host, and their environments [Hovland et al., 1994; Freiwald and Roberts, 2005].This effort has involved swath bathymetry, remotely operated vehicle deployments, shallow coring, and seismic surveys. Global coverage is difficult to gauge, but studies indicate that cold‐water corals may cover as large an area as the better known warm‐water corals that form shallow reefs (284,300 square kilometers) [Freiwald et al., 2005]. Cold‐water corals occur in a variety of forms and settings, from small isolated colonies or patch reefs to giant mound structures such as those found west of Ireland.