Intracellular melanization, a defense or an immune response in the thoracic muscle cells, was investigated in a refractory strain of Anopheles quadrimaculatus infected with larvae of Brugia malayi. In mosquitoes fed on B. malayi-infected jirds, intracellular melanization against first-stage larvae (L1) was better expressed when fewer than 40 microfilariae reached the thoracic muscle cells than when more than 40 microfilariae reached the thoracic muscle cells. This result suggests that when large numbers of microfilariae invade the thoracic muscle cells, the immune response of the mosquito may become overloaded. Intracellular melanization response against L1 in the thoracic muscle cells also showed a significant decrease in older females (14-16-day-old) as compared to the younger ones (4-9-day-old). A comparison is made between intracellular and extracellular responses of mosquitoes to filarial larvae. It is significant that in both cases high rate of infection can reduce both the number and percentage of larvae melanized.
Three groups of 96 crossbred gilts were weaned at 4 to 5 wk of age (average initial weight, 7.2 kg) and assigned to four dietary treatments in a 2 X 2 factorial arrangement of treatments (ad libitum vs 75% ad libitum and 100 vs 150% of NRC daily Ca and P). The effects of dietary treatments on the gait characteristics of gilts were analyzed by 16-mm motion picture photography. At approximately 50 and 100 kg body weight (periods 1 and 2, respectively), pigs were photographed walking on a treadmill, and gait characteristics were measured from the motion picture film. Ad libitum-fed gilts were longer, taller, wider and deeper when compared with restricted-fed gilts on an equal age basis, but not when compared on an equal weight basis. Other side view and rear view measurements were inconsistently affected by energy level (ad libitum vs restricted) at the two time periods, and all measurements were unaffected by Ca and P level. Analysis of the side and rear view characteristics over time generally revealed undesirable changes (P less than .01) from 59 to 100 kg. Both left and right hock-joint deviation increased (P less than .01) from period 1 to period 2, when expressed on an equal weight basis, suggesting the development of joint weakness. The hind pastern angle and the angle at the hock-joint also increased with time (P less than .01), suggesting development of post-leggedness as pigs increased in age and weight. Correlation coefficients among the various photographic characteristics and structural soundness scores were generally very low. Long-term effects of the dietary treatments on structural development are under study.
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