It is known that vascular endothelial growth factor (VEGF) expression is a response to hypoxia. On the other hand hypoxia may be detected by oximetry parameters including venous CO-oximetry indices or corresponding partial pressures of O2 and CO2. However significant correlation ties between VEGF levels and oximetry parameters were not found in groups of patients with ischemic stroke and transient ischemic attack. At that some effect related to the relationship between VEGF and sO2 was observed at corresponding scatter plots. Correlation between VEGF and proteins S100 levels in serum existed only in group with severe hypoxia where sO2 is less threshold close to 39-40%. So the relationship between VEGF level and saturation index sO2 exists in conjunction with additional factor that is S100 level in serum. To assess statistical significance of observed regularity it is necessary to test three null hypotheses about independence of one of involved factors on two another. The relationship may be manifestation of hypoxia effect on VEGF. To assess significance of hypoxia effect as a whole all three null hypotheses were tested with the help of developed technique based on random permutations and involving nonparametric combinations of criteria related to single oximetry parameters. The statistical significance assessments also involved multiplicity adjustment aimed to take into account multiple search of additional factors among variety of biological indices from analyzed data set. As a result of developed technique application all three considered null hypotheses were rejected at adjusted level p < 0.02 when effect of hypoxia on correlation between VEGF and complement component C4 was evaluated.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.