Surgical procedures are necessary in up to 50% of trigeminal neuralgia patients. Although radiofrequency (RF) is more widely used, it is associated with high intraprocedural costs and long technical learning time. Other simpler procedures such as balloon compression (BC) require a lower training period and have significant lower costs. We evaluated the effects of BC and RF in pain control in primary trigeminal neuralgia in a randomized, double-blinded, head-to-head trial. Individuals were randomly allocated in 1 of 2 groups: BC and RF. Throughout pain, psychological and quality of life measurements were performed at baseline and after surgery. The main outcome was the worst pain in the last 24 hours (0-10) at 6 months postoperatively. After the inclusion of half of the estimated sample, a preplanned interim analysis was performed when 33 patients (62.1 ± 9.4 y.) completed the study. Pain intensity (confidence interval [CI] 95% 0.6 to 3.8, and −0.6 to 2.2, for BC and RF) did not significantly differ. Complications, interference of pain in daily life (CI 95% −0.1 to 2.3 and −0.4 to 2.3, for BC and RF), neuropathic pain symptoms (CI 95% 1.7 to 3.6 and 3.0 to 5.7, for BC and RF), mood (CI 95% 4.8 to 11.5 and 5.5 to 15.1, BC and RF, respectively), medication use, and quality of life (CI 95% 80.4 to 93.1 and 83.9 to 94.2, for BC and RF) were also not different. Radiofrequency presented more paresthetic symptoms than BC at 30 days after intervention. Based on these results, the study was halted due to futility because BC was not superior to RF.

No abstract

No abstract

No abstract

Fig. 1. Bilateral deep brain stimulation (DBS) of the dentate nucleus and relation with dentatorubrothalamic tracts (DRTT). Three-dimensional depictions of electrode placement in the dentate nucleus and its relations to the dentate-rubro-thalamic tract (DRTT). Fig. 1A and B result from a co-registration of pre-operative MRI with patient-specific deterministic tractography and post-operative CT (Elements Software, Brainlab AG, Germany). Fig. 1C originates from a co-registration of pre-operative MRI and post-operative CT, however normalized to the MNI space and comparing electrode position with a normalized DRTT projection (LEAD DBS Software, Horn & Kuehn, Germany).