Hunt for thiols: A nucleophilic thiol attack on a weakly fluorescent near‐infrared (NIR) squaraine dye results in a conjugation break to form an adduct that absorbs in the UV/Vis region and is highly fluorescent. This fluorophore allows the selective detection of thiols either by colorimetry or fluorescence (see picture). The probe is suitable for the detection and estimation of the total aminothiol content in human blood plasma.
A Zn(2+)-specific molecular probe 3 was developed for the selective detection of CN(-) under aqueous conditions. The fluorescent Zn(2+) complex of 3 upon CN(-) addition generates a bright blue fluorescence that allows the detection of the latter and is useful for the screening of natural products with and without endogenous cyanide content.
A tailor made squaraine dye upon binding with Ca2+ self-assembles to form a spherical micellar assembly that reorganises to thermodynamically stable 1D cylindrical rods with high molar absorptivity.
Jagd auf Thiole: Beim nucleophilen Angriff eines Thiols auf einen schwach fluoreszierenden Nah‐IR‐Squarain‐Farbstoff entsteht ein weniger konjugiertes Addukt, das im UV/Vis‐Bereich absorbiert und stark fluoresziert. Damit lassen sich Thiole entweder kolorimetrisch oder anhand ihrer Fluoreszenz selektiv nachweisen (siehe Bild). Die Sonde eignet sich für den Nachweis von Aminothiolen im menschlichen Blutplasma und zum Abschätzen des Gesamtgehalts.
A pyrrole end-capped bipyridyl ligand incorporating a chiral handle exhibited high solid-state emission when compared to the achiral analogue 1b and to the racemic molecule 1c which allowed the design of a reusable fluorescent probe for the selective detection of Zn2+ under aqueous conditions.
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