A case of primary gastric plasmacytoma expressing various surface and cytoplasmic antigens is reported. With the use of formalin‐fixed and deparaffinized sections, 13 different antibodies were applied. Neoplastic plasma cells revealed monoclonal IgG and x light chain in the cytoplasm, and expressed epithelial membrane antigen, Ki 67 antigen, cytokeratin, CD 22 antigen, interleukin‐2 receptor antigen, leukocyte common antigen and Ki‐1 (CD 30) antigen. However, tumor cells were devoid of HLA‐DR antigen. These data suggest that the neoplastic plasma cells are at the plasmoblastic stage of maturation and express various surface and cytoplasmic phenotypes.
The influence upon nickel subsulfide (α‐Ni3S2; Ni‐SS)‐induced carcinogenesis in the soft tissue of bone fracture at the site of Ni‐SS exposure was studied using female Fischer rats. During the one year of the experiment, the group subjected to bone fracture exhibited the shortest tumor induction time and survival time, and a significantly higher metastatic rate. The present study may suggest a model for the metastasis of human soft tissue tumors.
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