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Highlights
We compared analytical sensitivity and clinical sensitivity for the three commercially available rapid antigen detection (RAD) kits for detection of SARS-CoV-2 virus.
The three RAD kits varied 102 to 105 fold less sensitive than RT-PCR.
Clinical sensitivity of RAD kits ranged from 22.9% to 71.4% for detecting respiratory specimens from COVID-19 patients.
Understanding the clinical characteristics of different RAD kits can increase the likelihood of positive results.
Virus evolution should be monitored because frequent reassortment, which contributes to virus diversity, creates the potential for more severe infections.
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