The cytotoxic activity against both HL-60 and P388 leukemias, a series of Tricycle quinolones as antitumor acridones and Dipiperidines as CCR2 antagonist were selected. A series 1 dataset was selected for Quantitative structural activity relationship (QSAR) analysis using combination of various descriptors such as steric, electronic and topological. Stepwise regression method was used to derive the most significant QSAR equation for predicting the anticancerous activity.
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