The present study aimed at preparing nanostructured lipid carrier gel for intranasal drug delivery system of amlodipine besylate, an antihypertensive drug. The amlodipine besylate loaded nanostructured lipid carriers were prepared by emulsion solvent diffusion and evaporation method followed by ultrasonication. The properties of nanostructured lipid carriers such as particle size, zeta potential and entrapment efficiency were investigated. The nanostructured lipid carrier dispersion was suitably gelled and characterized for drug content, pH, in-vitro and ex-vivo drug diffusion. FTIR and DSC studies showed no chemical interaction between amlodipine besylate and excipients in the formulation. The particle size, zeta potential and entrapment efficiency amlodipine besylate loaded nanostructured lipid carriers were found to be 424.3 nm, −14.2 mV and 52 5 ± 2 31% respectively. The drug content of amlodipine nanostructured lipid carriers gel was found to be 96 5 ± 0 5%. Toxicological study carried out on sheep nasal mucosa showed no evidence of toxicity of nanostructured lipid carrier based gel. Amlodipine nanostructured lipid carriers based gel showed a good potential for prolonged release as compared with pure drug solution and nanostructured lipid carrier dispersion.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.