The present review describes the homogenous catalytic methodologies for the synthesis of 2,2’‐bipyridines involving C−C bond formation from C−H bond. There are three main approaches to build well‐decorated 2,2’‐bipyridines from C−H bond cleavage: i) the formation of C2−C2′ bond by the dimerization of (activated) pyridines, ii) the C−H bond heteroarylation of activated pyridine, or iii) the late‐stage functionalization of (activated) 2,2’‐bipyridines including photoredox processes. Besides the scope and limitation of each methodologies, the relevant mechanisms of reaction are also discussed.
The Front Cover shows – drawn in a cartoon‐style illustration – the different strategies to synthesize 2,2′‐bipyridines involving a C−H bond functionalization step. On the left side, the three approaches are inlaying in green lines. The catalysts (transition metal) are drawn in a bubble to illustrate the challenge of maintaining their catalytic activity while 2,2’‐bipyridines can coordinate and affect their properties. On the right side, the 2,2′‐bipyridine is designed as an allegory featuring a pink Cardoon flower for ligands and a bee for metals, showing their mutual bonding. Anne‐Sophie Pochet is thanked for taking the original photography on which this cover is built. More information can be found in the Minireview by J.‐F. Soulé et al.
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