A convenient one pot method developed for synthesisof fused pyrroloquinazolinone and amino quinazolinone derivatives starting from 2‐bromo benzaldehyde, anthranilamide through in situ formation of2‐(2‐bromophenyl)quinazolin‐4(3H)‐one and subsequent reaction withdifferent amino acids/cyclic secondary amines under aerobic conditions. The multicomponent protocol mediated by copper (II) salt involves direct amination with 2‐(2‐bromophenyl)quinazolin‐4(3H)‐one, decarboxylation and cyclization to obtain polycyclic fused quinazolinone or aminated quinazolinone derivatives with the acceptable yields.
The straightforward grinding of terminal alkynes and ketones/isatin in the presence of base, without the use of any catalyst or a solvent, appears to be a viable method for producing tertiary propargylic alcohols. This energy and time‐efficient rapid reaction opens up a greener pathway for the synthesis of propargylic alcohols with moderate to good yields as compared to contemporary methodologies.
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