Antenatal diagnosis of INPLAT is paramount to minimize UT injury. Utilization of management modifications identified in this review may reduce urologic injury due to INPLAT.
Objective
To determine the effect of an endothelin type A receptor antagonist (ETA) on uterine artery resistive index (UARI) and mean arterial pressure (MAP) in a placental ischemia rat model of pre-eclampsia produced by Reductions in Uterine Perfusion Pressure (RUPP).
Study Design
UARI was assessed by Doppler velocimetry in the RUPP and normal pregnant controls (NP) on gestation days (GD) 12, 15 and 18. UARI was also determined on GD 18 in NP and RUPP pregnant dams after pretreatment with ETA. MAP was recorded on GD 19.
Results
The RUPP group had a higher MAP and UARI on GD 15 and 18 than the NP group. Pretreatment with ETA attenuated both the MAP and GD 18 UARI in the RUPP group without affecting these parameters in the NP group.
Conclusion
The improvement in UARI could be one potential mechanism for the reduction in MAP in response to ETA in pregnant dams with ischemic placentas.
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