The presence of dominant active compounds in standardised methanol extract from the leaves of Stizolophus balsamita (S. balsamita) was examined using HPLC with a diode-array detector. The extract and three dominant parthenolide derivatives were tested with Serotonin Research ELISA for their ability to inhibit the serotonin release from platelets. The antiserotonin effect of the extract was compared with that of parthenolide, a compound with proven antiserotonin and antimigraine effects. This study aimed to evaluate the ability of natural parthenolide derivatives to inhibit serotonin release from platelets. Izospiciformin, stizolin and stizolicin were analysed along with the standardised alcohol extract of S. balsamita leaves, which also contained four other parthenolide derivatives. All the analysed substances were found to inhibit serotonin release from platelets as compared with the control sample, which had 100% of serotonin released. Izospiciformin had the most significant impact (97.98% serotonin release inhibition). The effect of the methanol extract of S. balsamita on the serotonin release inhibition was also statistically significant.
It can be assumed that sesquiterpene lactones and natural phytosteroids (ecdysones) are the characteristic compounds of the plants from the Asteraceae family. They display certain pharmacological properties and thus are helpful in chemical descriptions of the Asteraceae tribes, subtribes and species. Also some phenolic glycosides found in genus Klasea Cass, and in genus Centaurea L. may be of medical and chemotaxonomical significance. Our studies on the species of the aforementioned taxons and the isolation of several compounds allowed for interesting conclusions of phytochemical and taxonomical nature.
S u m m a r yFrom the aerial parts of Zoegea leptaurea subsp. mesopotamica (Czerep.) Rech. (syn . Zoegea mesopotamica Czerep.), 9α-hydroxyparthenolide was isolated. This compound was identified by spectral methods ( 1 H NMR and 13 C NMR). This research confirmed earlier indications about the presence of 4,5-epoxygermacranolides in the Zoegea L. genus. Thus, distinctive chemistry feature of plants in this taxon has chemotaxonomic implications.
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