Objective To determine the rate of remission of recently diagnosed (<1 year) type-2 diabetes mellitus (T2DM) in overweight/obese individuals, with a 6 month program of weight loss and exercise. Subjects and Methods Subjects (N=12) were overweight/obese (BMI 35.8±4.3 kg/m2), sedentary, and unfit (peak VO2 20.7±4.7 ml/kg/min) and recently (< 1 year) diagnosed with T2DM. They were willing to participate in a lifestyle program of behavioral weight loss counseling and supervised exercise located at a cardiac rehabilitation program prior to consideration of diabetes medications. Glycated homoglobin (HbA1c) before and after the study intervention was the primary study outcome along with secondary metabolic, fitness and body composition variables. Results Subjects had a baseline HbA1c of 6.5-8.0% (mean 6.8±0.2). Subjects lost 9.7±5.2kgs body weight (9%) and improved peak aerobic capacity by 18%. Two subjects withdrew for medical reasons unrelated to the lifestyle program. Eight of 10 completers (80%) went into partial T2DM remission with the mean HbA1c decreasing from 6.8±0.2 to 6.2±0.3% (P<0.001). Conclusions For individuals with recently diagnosed T2DM willing to undertake a formal lifestyle program, 80% of study completers and 67% of our total population achieved at least a partial T2DM remission at 6 months. Further study of this intervention at the time of diagnosis of T2DM with randomized controls and longer-term follow-up is warranted.

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These complex procedures can be performed with acceptable mortality but also with significant risk for morbidity.

Although commitment, motivation, and self-efficacy to stop smoking were high, perceived threat of CHD and future invasive CV interventions were high, and perceived barriers to SC were low, most women continued to smoke after their heart catheterization. Referrals for assistance from healthcare providers to decrease anxiety and nicotine dependence and to address ongoing challenges to SC are needed.