†Deceased (see In Memoriam at the end of this document) *Representative of the Pediatric and Congenital Electrophysiology Society (PACES) ‡Representative of the European Heart Rhythm Association (EHRA) xRepresentative of the Society of Thoracic Surgeons (STS) {Representative of the American College of Cardiology (ACC) #Representative of the Latin American Heart Rhythm Society (LAHRS) **Representative of the Infectious Diseases Society of America (IDSA) ‡ ‡Representative of the American Heart Association (AHA) xxRepresentative of the American Society of Anesthesiologists (ASA) {{Representative of the Asia Pacific Heart Rhythm Society (APHRS)

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Perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery ACC/AHA S1.4-8 Non-ST-elevation acute coronary syndromes AHA/ACC S1.4-9 Heart failure ACC/AHA S1.4-10 ST-elevation myocardial infarction ACC/AHA S1.4-11 Device-based therapy for cardiac rhythm abnormalities ACC/AHA/HRS S1.4-2 Coronary artery bypass graft surgery ACC/AHA S1.4-12 Hypertrophic cardiomyopathy ACC/AHA S1.4-13 Percutaneous coronary intervention ACC/AHA/SCAI S1.4-14 Guidelines for CPR and emergency cardiovascular care-part 9: post-cardiac arrest care AHA S1.4-15 Other related references Expert consensus statement on cardiovascular implantable electronic device lead management and extraction HRS S1.4-16 Management of cardiac involvement associated with neuromuscular diseases AHA S1.4-17 Expert consensus statement on magnetic resonance imaging HRS S1.4-18 Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 9: arrhythmias and conduction defects ACC/AHA S1.4-19 Expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope HRS S1.4-20 Expert consensus statement on the recognition and management of arrhythmias in adult congenital heart disease PACES/HRS S1.4-21 Expert consensus statement on the use of implantable cardioverter-defibrillator therapy in patients who are not included or not well represented in clinical trials HRS/ACC/AHA S1.4-22 Expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis HRS S1.4-23 Cardiac pacing and cardiac resynchronization therapy ESC S1.4-24 Expert consensus statement on pacemaker device and mode selection HRS/ACCF S1.4-25 Expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies HRS/EHRA S1.4-26 Expert consensus statement on the management of cardiovascular implantable electronic devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy HRS S1.4-27 Recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement AHA/ACCF/HRS S1.4-28 Recommendations for the standardization and interpretation of the electrocardiogram: part V: electrocardiogram changes associated with cardiac chamber hypertrophy: a scientific statement

Background-For patients with symptomatic New York Heart Association class III or IV, ejection fraction Յ35%, and QRS Ն130 ms, cardiac resynchronization therapy (CRT) has become an established treatment option. However, use of these implant criteria fails to result in clinical or echocardiographic improvement in 30% to 45% of CRT patients. Methods and Results-The Predictors of Response to CRT (PROSPECT)-ECG is a substudy of the prospective observational PROSPECT trial. ECGs collected before, during, and after CRT implantation were analyzed. Primary outcomes were improvement in clinical composite score (CCS) and reduction of left ventricular end systolic volume (LVESV) of Ͼ15% after 6 months. Age, sex, cause of cardiomyopathy, myocardial infarction location, right ventricular function, mitral regurgitation, preimplantation QRS width, preimplantation PR interval, preimplantation right ventricular-paced QRS width, preimplantation axis categories, LV-paced QRS width, postimplantation axis categories, difference between biventricular (Bi-V) pacing and preimplantation QRS width, and QRS bundle branch morphological features were analyzed univariably in logistic regression models to predict outcomes. All significant predictors (␣ϭ0.1), age, and sex were used for multivariable analyses. Cardiomyopathy cause interaction and subanalyses were also performed.