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Our study indicates that the HLA-E system is altered in MS and could play a regulatory role in disease.

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in all or a particular subset of SSc patients. In contrast, IL-17 itself was not detected in the majority of SSc patients. Discussion: The combination of IL-17, IFNγ and TGFβ levels in CD45Ro and CD45Ra cells from SSc patients is useful to distinguish between lSSc, ldSSc or edSSc. Blocking Th17 inducing cytokines such as IL-6 and IL-23 may provide a useful tool to intervene in the progression of SSc.