The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body. Here, we review their key roles in fluid homeostasis, glandular secretions, signal transduction and sensation, barrier function, immunity and inflammation, cell migration, and angiogenesis. Evidence from a wide variety of studies now supports a view of the functions of AQPs being much more complex than simply mediating the passive flow of water across biological membranes. The discovery and development of small-molecule AQP inhibitors for research use and therapeutic development will lead to new insights into the basic biology of and novel treatments for the wide range of AQP-associated disorders.
I fired and continued to fire until the crowd dispersed and I consider this is the least amount of firing which would produce the necessary moral, and widespread effect it was my duty to produce, if I was to justify my action. If more troops had been at hand the casualties would be greater in proportion. It was no longer a question of merely dispersing the crowd; but one of producing a sufficient moral effect, from a military point of view, not only on those who were present but more specially throughout the Punjab. There could be no question of undue severity. 2 1 This article has benefited from the comments and suggestions of a number of colleagues, including
Maunsell, a lieutenant in the 23rd Native Infantry of the Bengal Army set out on horseback in October 1812 from Agra, in what were then called the North-western Provinces, on a visit of inspection to Etawah, seventy-five miles south-east, accompanied by two sepoy orderlies and a horse carrying his belongings and equipment. All three were armed, Maunsell with sword and holster pistols, the sepoys with the Brown Bess musket and bayonet.
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