Abstract:The present study investigates the contribution of AMPK response and mTOR (mammalian target of rapamycin) pathways through high protein diet to the pancreas cancer susceptibility. The hypothalamic modulation of the AMPK/ACC and mTOR signaling pathways induce by HPD and are followed by assaying the tumorigenicity. The results demonstrate that AMPK and mTOR cooperated in the hypothalamus during HPD and resulted in reducing AMPK activity, and increasing mTOR activity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.