To assess the effectiveness of radiosurgery with a rotating gamma system (RGS) for paediatric brain tumours and arteriovenous malformation (AVM), this work was carried out on 123 patients with brain tumours or AVM received radiosurgery at Bach Mai hospital. The median dose was 13 Gy from a range of 8 to 20 Gy. Endpoints include the effects of increased intracranial pressure, seizures, hemiplegia, and tumour size on the syndrome. Results exhibited that the percentages of patients with complete response, partial response, and disease progression out of 59 patients with headache accounted for 11.9, 69.5, and 18.6%, respectively. Of the 20 patients with seizures, 30% had complete response, 65% partial response, and 5% stable disease. Regarding brain tumour size, 9 months after treatment, those with complete response, partial response, stable disease, and disease progression made up 18.7, 50.4, 14.6, and 16.3% of the total patients, respectively. There was no statistically significant effect of radiation dose on the results. This study showed a high percentage of children with brain tumours and AVM undergoing radiosurgery with a RGS had symptomatic responses after treatment.
The study aimed to evaluate the safety and effectiveness of selective internal radiation therapy (SIRT) in patients with unresectable hepatocellular carcinoma (HCC) in Vietnam. A single-arm, multicenter, prospective observational study on the use of SIRT in patients with HCC was conducted with 6 months of patient follow-up. At baseline, eligible patients had Eastern Cooperative Oncology Group (ECOG) status ≤1, total bilirubin ≤2 mg/dL, tumor burden ≤50%, Child-Pugh score A or ≤B7, and Barcelona Clinic Liver Cancer stage A – C. Patients with extrahepatic disease, signs of liver failure, or previous external beam radiation to the liver were excluded. Primary outcomes were tumor response according to modified Response Evaluation Criteria in Solid Tumors criteria, changes in liver function, and adverse events (AEs) assessed using Common Terminology for AEs v4.03 and the investigators’ clinical judgment. The secondary outcome was the percentage of patients alive at 6 months. Two centers enrolled 30 patients (median age 60 years) in 2017 and 2018. All patients were Child-Pugh A; among them, 28 were ECOG 0. Most had hepatitis B (n = 17, 57%) or D (n = 10, 33%). Target lesion response at 6 months was 23% complete response, 37% partial response, 7% stable disease, and 7% progressive disease. Of the 8 patients (27%) not evaluated, 2 had become eligible for resection, 2 had contraindications to imaging, and 4 were lost to follow-up. Laboratory values, including α-fetoprotein, did not change significantly from baseline to 6 months. The most common AEs were abdominal pain (37%) and vomiting (17%). Nine episodes of abdominal pain in 6 patients were treatment-related. Serious AEs included progressive cirrhosis (n = 1) and progression of HCC (n = 5). All patients were alive at 6 months. In conclusion, the safety and clinical effectiveness of SIRT were confirmed in patients with unresectable HCC in Vietnam.
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