Today, both nonprescription and prescription drugs used by people for disease treatment, illicit or reward purposes have diverse effects on health permanently or long-lastingly. The effects may even continue and lead to the death or disabilities in child when a person is no longer use the substance. Substances that cause addiction trigger intense feeling of euphoria then lead to loss of control of selfbehavior and perception. Problem regarding to drug abuse, tobacco and alcohol has always been a hot issue in every country around the world. Apart from alcohol use, drug abuse and addiction cause high risk of accidents, injuries and social violence incidences. It affects to the brain, behaviors, birth defects, drug dependences. Our responsibility nowadays is to help reduce the burden of addiction in a proportion of the world's population. There have been many reports on drug of abuse and neuropsychopharmacology such as Parkinson and other related consequences and diseases. This review paper focuses on the effects of drug abuse and addiction, both Central Nervous System (CNS) stimulants and depressants.
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