A BSTRACTBackground: ADHD is a neuro-behavioral disorder that is typically manifested during childhood and often persists into adulthood, it is a complex disorder influenced by many genes, genetic and environmental risk factors co-occurring in a non-random fashion. The MTHFR gene C677T polymorphism affects both nucleotide synthesis and DNA methylation, and is associated with reduced folate bioavailability and folate metabolites. Objectives: To assess the relationship between Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphisms (C667T) allele and Attention Deficit Hyperactivity Disorder (ADHD) in a sample of Egyptian children. Methodology: Out of 402 reviewed patients regularly attending the Psychiatric clinic, According to criteria of inclusion and exclusion a sample of 30 ADHD children were enrolled in this study. The patients were selected by simple random sample during the period from January to August, 2015 with age ranged from 6-to 12-year old. A matching number of 30 healthy children with normal developmental and psychiatric evaluation, of compareble age and sex, were randomly recruited as a study control. MTHFR gene polymorphism (C677T) allele was investigated in the selected sample.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.